Film Coating as a New Approach to Prepare Tablets Containing Long-Term Stable Lactobacillus acidophilus
This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to manufacture administrable probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage. The results show that the film coated lact...
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| Veröffentlicht in: | Periodica polytechnica. Chemical engineering. 2015-01, Vol.59 (1), p.96-103 |
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| container_title | Periodica polytechnica. Chemical engineering. |
| container_volume | 59 |
| creator | Wagner, Istvan Nagy, Zsombor Kristof Suhajda, Agnes Pataki, Hajnalka Soti, Peter Vigh, Tamas Harasztos, Anna Helga Marosi, Gyorgy Balogh, Attila |
| description | This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to manufacture administrable probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage. The results show that the film coated lactose-based tablets contained viable bacteria and the survival rate after the process was 21%, which could be enhanced up to 59% by applying protective media (trehalose, sucrose, reconstituted skim milk (RSM) during dehydration. Additionally, protective agents improved the viability of bacteria during storage too. After one year, 20% of the embedded bacteria were active when stored at -20 degree C, and viability dropped only one order of magnitude when stored at 7 degree C. It was verified that the bacteria in film coated tablets were not sensitive to higher levels of humidity owing to the moisture-moderating PVA-based coating composite. |
| doi_str_mv | 10.3311/PPch.7315 |
| format | Article |
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It was verified that the bacteria in film coated tablets were not sensitive to higher levels of humidity owing to the moisture-moderating PVA-based coating composite.</description><identifier>ISSN: 0324-5853</identifier><identifier>EISSN: 1587-3765</identifier><identifier>DOI: 10.3311/PPch.7315</identifier><language>eng</language><publisher>Budapest: Periodica Polytechnica, Budapest University of Technology and Economics</publisher><subject>Bacteria ; Coating ; Lactobacillus acidophilus ; Protective ; Reagents ; Survival ; Tablets ; Viability</subject><ispartof>Periodica polytechnica. 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Chemical engineering.</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>59</volume><issue>1</issue><spage>96</spage><epage>103</epage><pages>96-103</pages><issn>0324-5853</issn><eissn>1587-3765</eissn><abstract>This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to manufacture administrable probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage. The results show that the film coated lactose-based tablets contained viable bacteria and the survival rate after the process was 21%, which could be enhanced up to 59% by applying protective media (trehalose, sucrose, reconstituted skim milk (RSM) during dehydration. Additionally, protective agents improved the viability of bacteria during storage too. After one year, 20% of the embedded bacteria were active when stored at -20 degree C, and viability dropped only one order of magnitude when stored at 7 degree C. 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| issn | 0324-5853 1587-3765 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals |
| subjects | Bacteria Coating Lactobacillus acidophilus Protective Reagents Survival Tablets Viability |
| title | Film Coating as a New Approach to Prepare Tablets Containing Long-Term Stable Lactobacillus acidophilus |
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