Production of CNT-taxol-embedded PCL microspheres using an ammonium-based room temperature ionic liquid: As a sustained drug delivery system

•Preparation of PCL microspheres containing w-CNT/taxol complexes using room temperature ionic liquid.•Loading capacity of 0.8–1.2% and entrapment efficiency of 16–24%.•Sustain taxol release without an initial burst over 60days.•Dose-dependent inhibitory effects of human breast cancer cells (MCF-7)....

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Veröffentlicht in:	Journal of colloid and interface science 2015-03, Vol.442, p.147-153
Hauptverfasser:	Kim, Seong Yeol, Hwang, Ji-Young, Seo, Jae-Won, Shin, Ueon Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	A sustained drug delivery system Ammonium Compounds - chemistry Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Breast Breast Neoplasms - drug therapy Cell Survival - drug effects Delayed-Action Preparations - chemistry Drug Delivery Systems Humans Ionic liquids Ionic Liquids - chemistry Mass production Mathematical models MCF-7 Cells Microspheres One-pot mass production Paclitaxel - administration & dosage Paclitaxel - pharmacology Polyesters - chemistry Room temperature ionic liquids Taxol Taxol-loaded PCL microspheres Temperature TOMAC Viability
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