Rapid determination of fenoldopam in human plasma by UPLC–MS/MS for pharmacokinetic analysis in patients

•We developed a rapid UPLC–MS/MS method for quantifying fenoldopam in human plasma.•The matrix effect and stability of fenoldopam in hemolyzed plasma was evaluated.•The method was successfully applied to the pharmacokinetic analysis of fenoldopam in the plasma of hypertensive patients. We developed...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-01, Vol.978-979, p.78-82
Hauptverfasser:	Wang, Xipei, Zheng, Zhijie, He, Guodong, Mai, Liping, Zhou, Zhiling, Zhong, Shilong, Lin, Qiuxiong, Shan, Zhixin, Deng, Chunyu, Yang, Min, Yu, Xiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Alkalizing Chromatography Chromatography, High Pressure Liquid - methods Drug Stability Elution Ethyl acetate Fenoldopam Fenoldopam - blood Fenoldopam - chemistry Fenoldopam - pharmacokinetics Hemolyzed plasma High speed tool steels Human Human plasma Humans Limit of Detection Linear Models Liquid-Liquid Extraction Patients Pharmacokinetics Reproducibility of Results Tandem Mass Spectrometry - methods UPLC–MS/MS
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