Inhibiting (pro)renin receptor-mediated p38 MAPK signaling decreases hypoxia/reoxygenation-induced apoptosis in H9c2 cells

The (pro)renin receptor is a new molecular member of the renin–angiotensin system and participates in regulating many physiological and pathological processes. However, the role of (pro)renin receptor-mediated signaling pathways in myocardial ischemic/reperfusion injury remains unclear. In this stud...

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Veröffentlicht in:	Molecular and cellular biochemistry 2015-05, Vol.403 (1-2), p.267-276
Hauptverfasser:	Liu, Yan, Zhang, Shenglin, Su, Dechun, Liu, Jinqiu, Cheng, Yunpeng, Zou, Lu, Li, Wenqiang, Jiang, Yinong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensins Animals Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Blotting, Western Cardiology Caspase 3 - metabolism Cell Hypoxia - drug effects Cell Line Cellular biology Fluorescent Antibody Technique Gene Knockdown Techniques Hypoxia Imidazoles - pharmacology Life Sciences MAP Kinase Signaling System - drug effects Medical Biochemistry Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oncology Oxygen - pharmacology p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Physiological aspects Proteins Pyridines - pharmacology Rats Receptors, Cell Surface - metabolism Ribonucleic acid RNA RNA, Small Interfering - metabolism Up-Regulation - drug effects
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