Age-related studies on the removal of 7-methylguanine from DNA of mouse kidney tissue following N-methyl- N-nitrosourea treatment

To investigate the effects of age on DNA repair of alkylation damage, C57BL/6NNia mice ranging from 9 months to 29 months of age were injected by the intraperitoneal route with single doses of N-methyl- N-nitrosourea (MNU). The rates of removal of 7-methylguanine (m 7Gua) in nuclear DNA from kidney...

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Veröffentlicht in:	Mutation research 1993-03, Vol.295 (2), p.81-91
Hauptverfasser:	Gaubatz, James W., Tan, Boen H.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Methylguanine Ageing Aging Animals Biological and medical sciences Carcinogenesis Cellular Senescence DNA alkylation DNA Damage DNA Repair Fundamental and applied biological sciences. Psychology Guanine - analogs & derivatives Guanine - metabolism Kidney Male Methylnitrosourea Mice Mice, Inbred C57BL Molecular and cellular biology Molecular genetics Mutagenesis. Repair N-Methyl- N-nitrosourea
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