Chronic agmatine treatment prevents behavioral manifestations of nicotine withdrawal in mice

Smoking cessation exhibits an aversive withdrawal syndrome characterized by both increases in somatic signs and affective behaviors including anxiety and depression. In present study, abrupt withdrawal of daily nicotine injections (2mg/kg, s.c., four times daily, for 10 days) significantly increased...

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Veröffentlicht in:	European journal of pharmacology 2015-05, Vol.754, p.190-198
Hauptverfasser:	Kotagale, Nandkishor R., Chopde, Chandrabhan T., Umekar, Milind J., Taksande, Brijesh G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine Agmatine - administration & dosage Agmatine - pharmacokinetics Agmatine - pharmacology Agmatine - therapeutic use Animals Anxiety Anxiety - chemically induced Anxiety - drug therapy Behavior, Animal - drug effects Brain - drug effects Brain - metabolism Depression Depression - chemically induced Depression - drug therapy Infusions, Intraventricular Male Mice Nicotine - adverse effects Nicotine withdrawal Somatic behavior Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - prevention & control Tobacco Use Disorder - drug therapy
Online-Zugang:	Volltext
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