Cocoa‐rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis

We have recently shown that cocoa flavanols may have anti‐diabetic potential by promoting survival and function of pancreatic beta‐cells in vitro. In this work, we investigated if a cocoa‐rich diet is able to preserve beta‐cell mass and function in an animal model of type 2 diabetes and the mechanis...

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Veröffentlicht in:	Molecular nutrition & food research 2015-04, Vol.59 (4), p.820-824
Hauptverfasser:	Fernández‐Millán, Elisa, Cordero‐Herrera, Isabel, Ramos, Sonia, Escrivá, Fernando, Alvarez, Carmen, Goya, Luis, Martín, María Angeles
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animals antioxidants Antioxidants - pharmacology apoptosis Apoptosis - drug effects Apoptotic pathway bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism bcl-X Protein - genetics bcl-X Protein - metabolism Cacao - chemistry Caspase 3 - genetics Caspase 3 - metabolism caspase-3 Diabetes Mellitus, Experimental - drug therapy Diet flavanols Glucose homeostasis Glutathione enzymes glutathione peroxidase Glutathione Peroxidase - metabolism hyperglycemia Hyperglycemia - drug therapy insulin resistance Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism islets of Langerhans Male noninsulin-dependent diabetes mellitus oxidative stress Oxidative Stress - drug effects Pancreas Plant Extracts - pharmacology Polyphenols - pharmacology Rats Rats, Zucker Type 2 diabetes mellitus
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