Mechanical hyperalgesia in rats with diabetic polyneuropathy is selectively inhibited by local peripheral nociceptin/orphanin FQ receptor and µ-opioid receptor agonism

Peripheral receptors may contribute to the effects of systemically administered centrally available analgesics. In the present study, we analysed the effect of local peripheral injection of the nociceptin/orphanin FQ peptide (NOP) receptor agonist Ro65-6570 and compared it to the µ-opioid peptide (M...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2015-05, Vol.754, p.61-65
Hauptverfasser:	Schiene, Klaus, Tzschentke, Thomas M., Schröder, Wolfgang, Christoph, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Analgesics - therapeutic use Animals Benzimidazoles - pharmacology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetic Neuropathies - complications Diabetic Neuropathies - drug therapy Diabetic polyneuropathic pain Dose-Response Relationship, Drug Hyperalgesia - complications Hyperalgesia - drug therapy Imidazoles - antagonists & inhibitors Imidazoles - pharmacology Imidazoles - therapeutic use Male Morphine - antagonists & inhibitors Morphine - pharmacology Morphine - therapeutic use Naloxone - pharmacology Pain Threshold - drug effects Piperidines - pharmacology Rats Receptors, Opioid - agonists Receptors, Opioid - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - metabolism Ro65-6570 (=compound 1a Rover et al., 2000 Spiro Compounds - antagonists & inhibitors Spiro Compounds - pharmacology Spiro Compounds - therapeutic use µ-opioid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!