Immunohistochemistry is highly sensitive and specific for the detection of NRASQ61R mutation in melanoma

Testing for NRAS is now integral part in the assessment of metastatic melanoma patients because there is evidence that NRAS -mutated patients may be sensitive to MEK inhibitors, and RAS mutation is a common mechanism of acquired resistance during treatment with BRAF inhibitors. This study evaluated...

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Veröffentlicht in:	Modern pathology 2015-04, Vol.28 (4), p.487-497
Hauptverfasser:	Massi, Daniela, Simi, Lisa, Sensi, Elisa, Baroni, Gianna, Xue, Gongda, Scatena, Cristian, Caldarella, Adele, Pinzani, Pamela, Fontanini, Gabriella, Carobbio, Alessandra, Urso, Carmelo, Mandalà, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/22 692/53 Adolescent Adult Aged Aged, 80 and over Female GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Immunohistochemistry Laboratory Medicine Male Medicine Medicine & Public Health Melanoma - genetics Melanoma - metabolism Melanoma - pathology Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Mutation original-article Pathology Sensitivity and Specificity Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Young Adult
Online-Zugang:	Volltext
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