Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub

Background: Autophagy is of importance in the regulation of cell differentiation and senescence in podocytes. It is possible that derangement of autophagy under different pathological conditions activates or enhances Epithelial-to-Mesenchymal Transition (EMT) in podocytes, resulting in glomerular sc...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (5), p.1773-1786
Hauptverfasser:	Li, Guangbi, Li, Cai-Xia, Xia, Min, Ritter, Joseph K, Gehr, Todd W. B., Boini, Krishna, Li, Pin-Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing - metabolism Autophagy (Cytology) Cadherins - metabolism CDC2 Protein Kinase - metabolism Cell Differentiation Cell Line Epithelial cells Epithelial-Mesenchymal Transition - drug effects Glomerulosclerosis Health aspects Humans Lysosomal enzymes Lysosomes Lysosomes - metabolism Macrolides - pharmacology Microscopy, Confocal Mitosis NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - genetics NF-kappa B - metabolism Original Paper Physiological aspects Podocyte transdifferentiation Podocytes - cytology Podocytes - metabolism RNA Interference RNA, Small Interfering - metabolism Selective autophagy Sequestosome-1 Protein Signal Transduction - drug effects Ubiquitin binding protein Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism Zonula Occludens-1 Protein - metabolism
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