Serum "Big Insulin-Like Growth Factor II" from Patients with Tumor Hypoglycemia Lacks Normal E-Domain O-Linked Glycosylation, a Possible Determinant of Normal Propeptide Processing

The insulin-like growth factor II (IGF-II) gene is overexpressed in many mesenchymal tumors and can lead to non-islet-cell tumor hypoglycemia (NICTH). ProIGF-II consists of the 67 aa of IGF-II with a carboxyl 89-aa extension, the E domain. A derivative of proIGF-II containing only the first 21 aa of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (12), p.5823-5827
Hauptverfasser:	Daughaday, William H., Trivedi, Bakula, Baxter, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analytical, structural and metabolic biochemistry Binding, Competitive Biological and medical sciences Carrier proteins Carrier Proteins - metabolism Chromatography Cytochromes Elution Endocrine system Endocrinology Fibrosarcoma - blood Fundamental and applied biological sciences. Psychology Genes Hemangiopericytoma - blood Humans Hypoglycemia Hypoglycemia - blood Hypoglycemia - etiology Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor II - biosynthesis Insulin-Like Growth Factor II - isolation & purification Insulin-Like Growth Factor II - metabolism Lectins Medical research Medical sciences Protein hormones. Growth factors. Cytokines Protein Precursors - biosynthesis Protein Precursors - isolation & purification Protein Precursors - metabolism Protein Processing, Post-Translational Proteins Radioimmunoassay Recombinant Proteins - metabolism Reference Values Somatomedins Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!