Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital

IP administration of hexobarbital to rats caused a mean sleeping time of 93.6 min (SD 21.5). IV infusion of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo( f)quinoxaline (NBQX) at a dose rate of 0.11 mg/kg/min starting 30 min after administration of hexobarbital prolonged the mean sleeping time to 132.2 mi...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1993-09, Vol.46 (1), p.73-76
Hauptverfasser:	Dall, Vivi, Ørntoft, Ulla, Schmidt, Anni, Nordholm, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptors Anesthetics. Neuromuscular blocking agents Animals Binding, Competitive - drug effects Biological and medical sciences Dose-Response Relationship, Drug Drug Interactions Female Hexobarbital Hexobarbital - antagonists & inhibitors Hexobarbital - pharmacology Infusions, Intravenous Interaction Medical sciences NBQX Neuropharmacology Pharmacology. Drug treatments Quinoxalines - administration & dosage Quinoxalines - blood Quinoxalines - pharmacology Rat Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Sleep - drug effects Sleeping time Time Factors
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