β-Amyloid-(1-42) is a Major Component of Cerebrovascular Amyloid Deposits: Implications for the Pathology of Alzheimer Disease

Reinvestigation of the chemical structure of β-amyloid peptide (Aβ) deposits in the vascular tissue of Alzheimer disease brains revealed that the 42-residue form Aβ-(1-42), rather than the more soluble Aβ-(1-40) form, is the predominant peptide. Following removal of the surrounding tissue with SDS a...

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