Chromium and hexavalent chromium
An oral dose of 2-5 g of Cr super(6+) (as a chromate compound) can be fatal to humans. Toxic symptoms in individuals ingesting at least 5 g of chromate compounds included gastrointestinal bleeding, massive fluid loss and death from cardiovascular shock. Kidney and liver damage developing 1-4 days af...
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| Veröffentlicht in: | Journal of applied toxicology 1993-05, Vol.13 (3), p.225-230 |
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| creator | von Burg, R. Liu, D. |
| description | An oral dose of 2-5 g of Cr super(6+) (as a chromate compound) can be fatal to humans. Toxic symptoms in individuals ingesting at least 5 g of chromate compounds included gastrointestinal bleeding, massive fluid loss and death from cardiovascular shock. Kidney and liver damage developing 1-4 days after exposure have been reported in individuals ingesting less than or equal to 2 g of a chromate compound. For sodium chromate and dichromate, potassium dichromate and ammonium dichromate, the oral LD sub(50) in rats ranges from 51 to 57 mg/kg body weight. In terms of chromium, the LD sub(50) ranged from 16.7 to 22.5 mg/kg body weight. For chromium trioxide (chromic acid), Kobayashi reported an LD sub(50) ranging from 135 to 177 mg/kg body weight in rats (70-92 mg/kg as Cr) and from 80 to 114 mg/kg in mice (42-59 mg/kg as Cr). |
| doi_str_mv | 10.1002/jat.2550130315 |
| format | Article |
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Toxic symptoms in individuals ingesting at least 5 g of chromate compounds included gastrointestinal bleeding, massive fluid loss and death from cardiovascular shock. Kidney and liver damage developing 1-4 days after exposure have been reported in individuals ingesting less than or equal to 2 g of a chromate compound. For sodium chromate and dichromate, potassium dichromate and ammonium dichromate, the oral LD sub(50) in rats ranges from 51 to 57 mg/kg body weight. In terms of chromium, the LD sub(50) ranged from 16.7 to 22.5 mg/kg body weight. For chromium trioxide (chromic acid), Kobayashi reported an LD sub(50) ranging from 135 to 177 mg/kg body weight in rats (70-92 mg/kg as Cr) and from 80 to 114 mg/kg in mice (42-59 mg/kg as Cr).</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550130315</identifier><identifier>PMID: 8326094</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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Appl. Toxicol</addtitle><description>An oral dose of 2-5 g of Cr super(6+) (as a chromate compound) can be fatal to humans. Toxic symptoms in individuals ingesting at least 5 g of chromate compounds included gastrointestinal bleeding, massive fluid loss and death from cardiovascular shock. Kidney and liver damage developing 1-4 days after exposure have been reported in individuals ingesting less than or equal to 2 g of a chromate compound. For sodium chromate and dichromate, potassium dichromate and ammonium dichromate, the oral LD sub(50) in rats ranges from 51 to 57 mg/kg body weight. In terms of chromium, the LD sub(50) ranged from 16.7 to 22.5 mg/kg body weight. For chromium trioxide (chromic acid), Kobayashi reported an LD sub(50) ranging from 135 to 177 mg/kg body weight in rats (70-92 mg/kg as Cr) and from 80 to 114 mg/kg in mice (42-59 mg/kg as Cr).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chromium - chemistry</subject><subject>Chromium - immunology</subject><subject>Chromium - toxicity</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Toxicology</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PwkAQxTdGg4hevZn0YLwVZz-67R4JURRRL6jcNst2NhRbwG5R-O-tocF48jTJvN-beXmEnFPoUgB2PTdVl0URUA6cRgekTUGpkDLJD0kbmIRQ8HhyTE68nwPUGktapJXwWlGiTYL-rFwW2boIzCINZrgxnybHRRXYZn9KjpzJPZ41s0Nebm_G_btw9Dy47_dGoRU8iUKMjJAUEyMAXWQhVeBiGQtFjXQYcccMUKQO7RQlR57QlAolmbJMIBrkHXK1u7sqlx9r9JUuMm8xz80Cl2uvqZSKCRbXYHcH2nLpfYlOr8qsMOVWU9A_lei6Ev1bSW24aC6vpwWme7zpoNYvG914a3JXmoXN_B4TMReQqBpTO-wry3H7z1M97I3_RAh33sxXuNl7TfmuZczjSL89DfRw8tp_fBhDHewbqPKHsA</recordid><startdate>199305</startdate><enddate>199305</enddate><creator>von Burg, R.</creator><creator>Liu, D.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199305</creationdate><title>Chromium and hexavalent chromium</title><author>von Burg, R. ; Liu, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4385-e5a461e8a40ef5c0d90f767491a6fe53f2a01e1fecbe63e381d149629c24eeae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chromium - chemistry</topic><topic>Chromium - immunology</topic><topic>Chromium - toxicity</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Burg, R.</creatorcontrib><creatorcontrib>Liu, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Burg, R.</au><au>Liu, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromium and hexavalent chromium</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1993-05</date><risdate>1993</risdate><volume>13</volume><issue>3</issue><spage>225</spage><epage>230</epage><pages>225-230</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>An oral dose of 2-5 g of Cr super(6+) (as a chromate compound) can be fatal to humans. Toxic symptoms in individuals ingesting at least 5 g of chromate compounds included gastrointestinal bleeding, massive fluid loss and death from cardiovascular shock. Kidney and liver damage developing 1-4 days after exposure have been reported in individuals ingesting less than or equal to 2 g of a chromate compound. For sodium chromate and dichromate, potassium dichromate and ammonium dichromate, the oral LD sub(50) in rats ranges from 51 to 57 mg/kg body weight. In terms of chromium, the LD sub(50) ranged from 16.7 to 22.5 mg/kg body weight. For chromium trioxide (chromic acid), Kobayashi reported an LD sub(50) ranging from 135 to 177 mg/kg body weight in rats (70-92 mg/kg as Cr) and from 80 to 114 mg/kg in mice (42-59 mg/kg as Cr).</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8326094</pmid><doi>10.1002/jat.2550130315</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromium - chemistry Chromium - immunology Chromium - toxicity Humans Medical sciences Metals and various inorganic compounds Toxicology |
| title | Chromium and hexavalent chromium |
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