c‐myc‐induced natural killer cell sensitivity of human melanoma cells is reversed by HLA‐B27 transfection

In human melanoma, activation of the c‐myc oncogene results in locus‐specific down‐modulation of the HLA‐B antigen expression. Moreover, overexpression of c‐myc induces an increase of natural killer (NK) sensitivity of the tumor cells. To show that this effect on susceptibility to NK cells is mediat...

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Veröffentlicht in:	European journal of immunology 1992-10, Vol.22 (10), p.2737-2740
Hauptverfasser:	Peltenburg, Lucy T. C., Steegenga, Wilma T., Margaretha Krüse, K., Schrier, Peter I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Genes, myc HLA-A Antigens - analysis HLA-B27 Antigen - analysis HLA-B27 Antigen - genetics Humans Immunobiology Killer Cells, Natural - immunology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Melanoma - immunology Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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