Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M sub(1) muscarinic receptor agonists

A series of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines was synthesized for biological evaluation as selective agonists for M sub(1) receptors coupled to phosphoinositide (PI) metabolism in the central nervous system. Each ligand bound with high affinity to muscarinic receptors fr...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-01, Vol.36 (7), p.842-847
Hauptverfasser:	Dunbar, P G, Durant, G J, Fang, Zheng, Abuh, Y F, El-Assadi, A A, Ngur, DO, Periyasamy, S, Hoss, W P, Messer, WS Jr
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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