Cdk-activating kinase complex is a component of human transcription factor TFIIH

Transcription factor IIH (TFIIH) contains a kinase capable of phosphorylating the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII). Here we report the identification of the Cdk-activating kinase (Cak) complex (Cdk7 and cyclin H) as a component of TFIIH after extensi...

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Veröffentlicht in:	Nature (London) 1995-03, Vol.374 (6519), p.283-287
Hauptverfasser:	Shiekhattar, Ramin, Mermelstein, Fred, Fisher, Robert P, Drapkin, Ronny, Dynlacht, Brian, Wessling, Holly C, Morgan, David O, Reinberg, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemistry Biological and medical sciences Cellular biology Chromatography Chromatography, Affinity Cyclin H Cyclin-Dependent Kinases Cyclins - metabolism Detergents Fundamental and applied biological sciences. Psychology HeLa Cells Humans Immunologic Techniques Molecular and cellular biology Molecular genetics Molecular Sequence Data Phosphorylation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - isolation & purification Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins - metabolism Ribonucleic acid RNA RNA Polymerase II - metabolism Sarcosine - analogs & derivatives Transcription Factor TFIIH Transcription Factors - chemistry Transcription Factors - metabolism Transcription Factors, TFII Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing
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