Species differences in the metabolism and hepatotoxicity of coumarin

1. Investigations of coumarin metabolism and hepatotoxicity have been reviewed. 2. Species differences in coumarin hepatotoxicity appear to be metabolism-mediated. 3. The rat, in which it is markedly hepatotoxic, primarily metabolises coumarin via 3-hydroxylation and cleavage of the heterocyclic rin...

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Veröffentlicht in:	Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology Comparative Pharmacology, 1993, Vol.104 (1), p.1-8
Hauptverfasser:	Fentem, Julia H., Fry, Jeffrey R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical and Drug Induced Liver Injury Coumarins - metabolism Coumarins - toxicity Domestic and cosmetic products toxicology Humans In Vitro Techniques Liver Diseases - metabolism Medical sciences Papio Species Specificity Toxicology
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