Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents
Research and development of potent and effective antimicrobial agents represent one of the most important advances in therapeutics; the main aim of these efforts is not only control the serious infections, but also prevention and treatment of some infectious complications of other therapeutic modali...
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| Veröffentlicht in: | Journal of applied pharmaceutical science 2013-11, Vol.3 (11), p.15-109 |
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| creator | A, Bushra Begum Khanum, Noor Fatima P, Naveen V, Lakshmi Ranganatha MS, Asha Khanum, Shaukath Ara |
| description | Research and development of potent and effective antimicrobial agents represent one of the most important advances in therapeutics; the main aim of these efforts is not only control the serious infections, but also prevention and treatment of some infectious complications of other therapeutic modalities. A series of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles were screened for their antibacterial and antifungal activities. Anti-bacterial activity against B. cereus, S. aureus, B. subtilis, S. aureus (MRSA), E. aerogenes, M. luteus, K. pneumonia, P. aeruginosa, S. typhimurium, E. coli, paratyphi-B, P. vulgaris bacterial strains and anti-fungal activity against C. albicans, A.niger, F.solani, A.flavus, B.cinerea, C.krusei, M. pachydermatis, C.parapsilosis, F.moniliforme, C.gloeosporioides fungal strains were carried out. The bioassays indicated that most of the synthesized compounds showed potential antibacterial and anti-fungal activity. |
| doi_str_mv | 10.7324/JAPS.2013.31119 |
| format | Article |
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| ispartof | Journal of applied pharmaceutical science, 2013-11, Vol.3 (11), p.15-109 |
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| source | Free Full-Text Journals in Chemistry |
| subjects | Escherichia coli Pseudomonas aeruginosa Salmonella typhimurium Staphylococcus aureus |
| title | Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents |
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