EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface

Many cancers are dependent on inappropriate activation of epidermal growth factor receptor (EGFR), and drugs targeting this receptor can improve patient survival, although benefits are generally short-lived. We reveal a novel mechanism linking EGFR and the membrane-spanning, cancer-promoting protein...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2015-03, Vol.34 (11), p.1375-1383
Hauptverfasser:	Adams, M N, Harrington, B S, He, Y, Davies, C M, Wallace, S J, Chetty, N P, Crandon, A J, Oliveira, N B, Shannon, C M, Coward, J I, Lumley, J W, Perrin, L C, Armes, J E, Hooper, J D
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/95 38/70 631/80/313/1461 Animals Antibodies, Monoclonal - immunology Antigens, CD - immunology Antigens, CD - metabolism Apoptosis Cancer Care and treatment Cell adhesion & migration Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Biology Cell cycle Cell Line, Tumor Cell Membrane - metabolism Cell migration Cell Movement Cell surface Drug delivery Enzyme Activation Epidermal growth factor Epidermal Growth Factor - pharmacology Epidermal growth factor receptors ErbB Receptors - metabolism Female Genetic aspects Human Genetics Humans Interleukin-6 - pharmacology Internal Medicine Internalization Life span Lipoylation Medicine Medicine & Public Health Membrane proteins Membrane Proteins - metabolism Membranes Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Neoplasm Transplantation Oncology original-article Ovarian cancer Ovarian Neoplasms - pathology Ovarian tumors Palmitoylation Proteasomes Protein Transport Proteins Risk factors Sodium Transplantation, Heterologous Tumor Necrosis Factor-alpha - pharmacology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!