Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock
Abstract Background This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. Methods We designed a prospective cohort study in an intensive care unit, and 54 patients...
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| Veröffentlicht in: | Journal of critical care 2015-04, Vol.30 (2), p.271-275 |
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| creator | Wang, Biao, MD Chen, Gang, MD Cao, Yifei, MD Xue, Jiping, MD Li, Jia, MD Wu, Yunfu, MD |
| description | Abstract Background This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. Methods We designed a prospective cohort study in an intensive care unit, and 54 patients with severe sepsis or septic shock were included. Data were used to determine a relationship between lactate/albumin ratio and the development of MODS and mortality. These associations were determined by the Mann-Whitney test, multiple logistic regression, plotting the receiver operating characteristic curve and Spearman test. Results Lactate/albumin ratio level was higher in MODS patients on day 1 (median [interquartile range, or IQR], 2.295 [1.818-3.065]; n = 30, P < .0001) than in those without (median [IQR], 1.550 (1.428-1.685); n = 24), and on day 2, (median [IQR], 1.810 [1.377-2.448]; n = 26, P = .0022) it was higher than in those without (median [IQR], 1.172 (1.129-1.382); n = 23) on day 2. We found that lactate/albumin ratio was an independent predictor of the development of MODS (odds ratio, 5.5; P = .033; 95% confidence interval, 1.1-26.1) during intensive care unit stay. The area under the receiver operating characteristic curve showed that lactate/albumin ratio could predict MODS (0.8458) and mortality (0.8449). Furthermore, the higher the Acute Physiology and Chronic Health Evaluation II score, the more lactate/albumin ratio was discovered on day 1 ( r = 0.5315, P < .0001) and day 2 ( r = 0.5408, P < .0001), whereas the lower partial pressure of oxygen in arterial blood/fraction of inspired oxygen ratio, the more lactate/albumin ratio was illustrated on day 1 ( r = − 0.5143, P < .0001) and day 2 ( r = − 0.5420, P < .0001). Conclusions Increased lactate/albumin ratio correlates with the development of MODS and mortality in patients with severe sepsis and septic shock. |
| doi_str_mv | 10.1016/j.jcrc.2014.10.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1668265502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0883944114004389</els_id><sourcerecordid>3594494551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-adb248556ae3ec64d37476f920b2ff30c8a747014a2c88b3ba9c3a2683d043f3</originalsourceid><addsrcrecordid>eNqNkk-LFDEQxYMo7uzoF_AgAS9eejb_OwMiLIOrwoIH9x7S6WpNT6YzJumF-famnVVhD-Ip4dWvCl69QugVJRtKqLoaN6NLbsMIFVXYEE6eoBWVsm20ovIpWhGtebMVgl6gy5xHQmjLuXyOLpiUvJWtWKH9LqYEwRYfJxwHHKwrtsCVDd188BNOSwUHuIeAS8QxfbMTHqwPcwJspx4fYio2-HLClc6Vq3qGY_b5V7l-i3c4f49u_wI9G2zI8PLhXaO7mw93u0_N7ZePn3fXt42TgpXG9h0TWkplgYNTouetaNWwZaRjw8CJ07YK1bRlTuuOd3bruGVK854IPvA1ensee0zxxwy5mIPPDkKwE8Q5G6qUZkpKwv4DlS1ndNnjGr15hI5xTlP1sVCyVZRxUSl2plyKOScYzDH5g00nQ4lZQjOjWUIzS2iLVkOrTa8fRs_dAfo_Lb9TqsC7MwB1a_ceksnOw-Sg9wlcMX30_57__lG7C37yzoY9nCD_9WEyM8R8XewuV0MFqQvVW_4T0ya8iQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1655761234</pqid></control><display><type>article</type><title>Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wang, Biao, MD ; Chen, Gang, MD ; Cao, Yifei, MD ; Xue, Jiping, MD ; Li, Jia, MD ; Wu, Yunfu, MD</creator><creatorcontrib>Wang, Biao, MD ; Chen, Gang, MD ; Cao, Yifei, MD ; Xue, Jiping, MD ; Li, Jia, MD ; Wu, Yunfu, MD</creatorcontrib><description>Abstract Background This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. Methods We designed a prospective cohort study in an intensive care unit, and 54 patients with severe sepsis or septic shock were included. Data were used to determine a relationship between lactate/albumin ratio and the development of MODS and mortality. These associations were determined by the Mann-Whitney test, multiple logistic regression, plotting the receiver operating characteristic curve and Spearman test. Results Lactate/albumin ratio level was higher in MODS patients on day 1 (median [interquartile range, or IQR], 2.295 [1.818-3.065]; n = 30, P < .0001) than in those without (median [IQR], 1.550 (1.428-1.685); n = 24), and on day 2, (median [IQR], 1.810 [1.377-2.448]; n = 26, P = .0022) it was higher than in those without (median [IQR], 1.172 (1.129-1.382); n = 23) on day 2. We found that lactate/albumin ratio was an independent predictor of the development of MODS (odds ratio, 5.5; P = .033; 95% confidence interval, 1.1-26.1) during intensive care unit stay. The area under the receiver operating characteristic curve showed that lactate/albumin ratio could predict MODS (0.8458) and mortality (0.8449). Furthermore, the higher the Acute Physiology and Chronic Health Evaluation II score, the more lactate/albumin ratio was discovered on day 1 ( r = 0.5315, P < .0001) and day 2 ( r = 0.5408, P < .0001), whereas the lower partial pressure of oxygen in arterial blood/fraction of inspired oxygen ratio, the more lactate/albumin ratio was illustrated on day 1 ( r = − 0.5143, P < .0001) and day 2 ( r = − 0.5420, P < .0001). Conclusions Increased lactate/albumin ratio correlates with the development of MODS and mortality in patients with severe sepsis and septic shock.</description><identifier>ISSN: 0883-9441</identifier><identifier>EISSN: 1557-8615</identifier><identifier>DOI: 10.1016/j.jcrc.2014.10.030</identifier><identifier>PMID: 25537574</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; APACHE ; Blood ; Confidence intervals ; Critical Care ; Female ; Heart attacks ; Humans ; Hypoxia ; Inflammation ; Intensive Care Units ; Lactate/albumin ratio ; Lactic Acid - blood ; Logistic Models ; Male ; Middle Aged ; MODS ; Mortality ; Multiple Organ Failure - blood ; Multiple Organ Failure - mortality ; Multivariate Analysis ; Prospective Studies ; Resuscitation ; ROC Curve ; Sepsis ; Sepsis - blood ; Sepsis - mortality ; Serum Albumin - analysis ; Severe sepsis and septic shock ; Shock, Septic - blood ; Shock, Septic - mortality ; Software ; Studies ; Variables ; Ventilation</subject><ispartof>Journal of critical care, 2015-04, Vol.30 (2), p.271-275</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-adb248556ae3ec64d37476f920b2ff30c8a747014a2c88b3ba9c3a2683d043f3</citedby><cites>FETCH-LOGICAL-c542t-adb248556ae3ec64d37476f920b2ff30c8a747014a2c88b3ba9c3a2683d043f3</cites><orcidid>0000-0003-4893-5262</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0883944114004389$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25537574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Biao, MD</creatorcontrib><creatorcontrib>Chen, Gang, MD</creatorcontrib><creatorcontrib>Cao, Yifei, MD</creatorcontrib><creatorcontrib>Xue, Jiping, MD</creatorcontrib><creatorcontrib>Li, Jia, MD</creatorcontrib><creatorcontrib>Wu, Yunfu, MD</creatorcontrib><title>Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock</title><title>Journal of critical care</title><addtitle>J Crit Care</addtitle><description>Abstract Background This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. Methods We designed a prospective cohort study in an intensive care unit, and 54 patients with severe sepsis or septic shock were included. Data were used to determine a relationship between lactate/albumin ratio and the development of MODS and mortality. These associations were determined by the Mann-Whitney test, multiple logistic regression, plotting the receiver operating characteristic curve and Spearman test. Results Lactate/albumin ratio level was higher in MODS patients on day 1 (median [interquartile range, or IQR], 2.295 [1.818-3.065]; n = 30, P < .0001) than in those without (median [IQR], 1.550 (1.428-1.685); n = 24), and on day 2, (median [IQR], 1.810 [1.377-2.448]; n = 26, P = .0022) it was higher than in those without (median [IQR], 1.172 (1.129-1.382); n = 23) on day 2. We found that lactate/albumin ratio was an independent predictor of the development of MODS (odds ratio, 5.5; P = .033; 95% confidence interval, 1.1-26.1) during intensive care unit stay. The area under the receiver operating characteristic curve showed that lactate/albumin ratio could predict MODS (0.8458) and mortality (0.8449). Furthermore, the higher the Acute Physiology and Chronic Health Evaluation II score, the more lactate/albumin ratio was discovered on day 1 ( r = 0.5315, P < .0001) and day 2 ( r = 0.5408, P < .0001), whereas the lower partial pressure of oxygen in arterial blood/fraction of inspired oxygen ratio, the more lactate/albumin ratio was illustrated on day 1 ( r = − 0.5143, P < .0001) and day 2 ( r = − 0.5420, P < .0001). Conclusions Increased lactate/albumin ratio correlates with the development of MODS and mortality in patients with severe sepsis and septic shock.</description><subject>Adult</subject><subject>Aged</subject><subject>APACHE</subject><subject>Blood</subject><subject>Confidence intervals</subject><subject>Critical Care</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Intensive Care Units</subject><subject>Lactate/albumin ratio</subject><subject>Lactic Acid - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MODS</subject><subject>Mortality</subject><subject>Multiple Organ Failure - blood</subject><subject>Multiple Organ Failure - mortality</subject><subject>Multivariate Analysis</subject><subject>Prospective Studies</subject><subject>Resuscitation</subject><subject>ROC Curve</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - mortality</subject><subject>Serum Albumin - analysis</subject><subject>Severe sepsis and septic shock</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - mortality</subject><subject>Software</subject><subject>Studies</subject><subject>Variables</subject><subject>Ventilation</subject><issn>0883-9441</issn><issn>1557-8615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk-LFDEQxYMo7uzoF_AgAS9eejb_OwMiLIOrwoIH9x7S6WpNT6YzJumF-famnVVhD-Ip4dWvCl69QugVJRtKqLoaN6NLbsMIFVXYEE6eoBWVsm20ovIpWhGtebMVgl6gy5xHQmjLuXyOLpiUvJWtWKH9LqYEwRYfJxwHHKwrtsCVDd188BNOSwUHuIeAS8QxfbMTHqwPcwJspx4fYio2-HLClc6Vq3qGY_b5V7l-i3c4f49u_wI9G2zI8PLhXaO7mw93u0_N7ZePn3fXt42TgpXG9h0TWkplgYNTouetaNWwZaRjw8CJ07YK1bRlTuuOd3bruGVK854IPvA1ensee0zxxwy5mIPPDkKwE8Q5G6qUZkpKwv4DlS1ndNnjGr15hI5xTlP1sVCyVZRxUSl2plyKOScYzDH5g00nQ4lZQjOjWUIzS2iLVkOrTa8fRs_dAfo_Lb9TqsC7MwB1a_ceksnOw-Sg9wlcMX30_57__lG7C37yzoY9nCD_9WEyM8R8XewuV0MFqQvVW_4T0ya8iQ</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Wang, Biao, MD</creator><creator>Chen, Gang, MD</creator><creator>Cao, Yifei, MD</creator><creator>Xue, Jiping, MD</creator><creator>Li, Jia, MD</creator><creator>Wu, Yunfu, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0003-4893-5262</orcidid></search><sort><creationdate>20150401</creationdate><title>Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock</title><author>Wang, Biao, MD ; Chen, Gang, MD ; Cao, Yifei, MD ; Xue, Jiping, MD ; Li, Jia, MD ; Wu, Yunfu, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-adb248556ae3ec64d37476f920b2ff30c8a747014a2c88b3ba9c3a2683d043f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>APACHE</topic><topic>Blood</topic><topic>Confidence intervals</topic><topic>Critical Care</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Inflammation</topic><topic>Intensive Care Units</topic><topic>Lactate/albumin ratio</topic><topic>Lactic Acid - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MODS</topic><topic>Mortality</topic><topic>Multiple Organ Failure - blood</topic><topic>Multiple Organ Failure - mortality</topic><topic>Multivariate Analysis</topic><topic>Prospective Studies</topic><topic>Resuscitation</topic><topic>ROC Curve</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - mortality</topic><topic>Serum Albumin - analysis</topic><topic>Severe sepsis and septic shock</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - mortality</topic><topic>Software</topic><topic>Studies</topic><topic>Variables</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Biao, MD</creatorcontrib><creatorcontrib>Chen, Gang, MD</creatorcontrib><creatorcontrib>Cao, Yifei, MD</creatorcontrib><creatorcontrib>Xue, Jiping, MD</creatorcontrib><creatorcontrib>Li, Jia, MD</creatorcontrib><creatorcontrib>Wu, Yunfu, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of critical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Biao, MD</au><au>Chen, Gang, MD</au><au>Cao, Yifei, MD</au><au>Xue, Jiping, MD</au><au>Li, Jia, MD</au><au>Wu, Yunfu, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock</atitle><jtitle>Journal of critical care</jtitle><addtitle>J Crit Care</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>30</volume><issue>2</issue><spage>271</spage><epage>275</epage><pages>271-275</pages><issn>0883-9441</issn><eissn>1557-8615</eissn><abstract>Abstract Background This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. Methods We designed a prospective cohort study in an intensive care unit, and 54 patients with severe sepsis or septic shock were included. Data were used to determine a relationship between lactate/albumin ratio and the development of MODS and mortality. These associations were determined by the Mann-Whitney test, multiple logistic regression, plotting the receiver operating characteristic curve and Spearman test. Results Lactate/albumin ratio level was higher in MODS patients on day 1 (median [interquartile range, or IQR], 2.295 [1.818-3.065]; n = 30, P < .0001) than in those without (median [IQR], 1.550 (1.428-1.685); n = 24), and on day 2, (median [IQR], 1.810 [1.377-2.448]; n = 26, P = .0022) it was higher than in those without (median [IQR], 1.172 (1.129-1.382); n = 23) on day 2. We found that lactate/albumin ratio was an independent predictor of the development of MODS (odds ratio, 5.5; P = .033; 95% confidence interval, 1.1-26.1) during intensive care unit stay. The area under the receiver operating characteristic curve showed that lactate/albumin ratio could predict MODS (0.8458) and mortality (0.8449). Furthermore, the higher the Acute Physiology and Chronic Health Evaluation II score, the more lactate/albumin ratio was discovered on day 1 ( r = 0.5315, P < .0001) and day 2 ( r = 0.5408, P < .0001), whereas the lower partial pressure of oxygen in arterial blood/fraction of inspired oxygen ratio, the more lactate/albumin ratio was illustrated on day 1 ( r = − 0.5143, P < .0001) and day 2 ( r = − 0.5420, P < .0001). Conclusions Increased lactate/albumin ratio correlates with the development of MODS and mortality in patients with severe sepsis and septic shock.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25537574</pmid><doi>10.1016/j.jcrc.2014.10.030</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4893-5262</orcidid></addata></record> |
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| subjects | Adult Aged APACHE Blood Confidence intervals Critical Care Female Heart attacks Humans Hypoxia Inflammation Intensive Care Units Lactate/albumin ratio Lactic Acid - blood Logistic Models Male Middle Aged MODS Mortality Multiple Organ Failure - blood Multiple Organ Failure - mortality Multivariate Analysis Prospective Studies Resuscitation ROC Curve Sepsis Sepsis - blood Sepsis - mortality Serum Albumin - analysis Severe sepsis and septic shock Shock, Septic - blood Shock, Septic - mortality Software Studies Variables Ventilation |
| title | Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock |
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