Sirt3 controls chromosome alignment by regulating spindle dynamics during mitosis

•Sirt3 is not a tubulin deacetylase but regulates spindle dynamics.•Depletion of the Sirt3 proteins with siRNA causes defects of mitotic progression.•Sirt3 is involved in spindle polymerization and chromosome alignment. Sirt3, one of mammalian sirtuins is a prominent mitochondrial deacetylase that c...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-02, Vol.444 (4), p.662-669
Hauptverfasser:	Choi, Byung-Soo, Park, Ji Eun, Jang, Chang-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome alignment Chromosomes - metabolism Chromosomes - ultrastructure HeLa Cells Humans Mitosis RNA Interference RNA, Small Interfering - genetics Sirt3 Sirtuin 3 - genetics Sirtuin 3 - metabolism Spindle Apparatus - metabolism Spindle Apparatus - ultrastructure Spindle assembly checkpoint Spindle dynamics
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