Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B
Background and Aim Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2015-04, Vol.30 (4), p.756-762 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Jia, Jidong Hou, Jinlin Ding, Huiguo Chen, Guofeng Xie, Qing Wang, Yuming Zeng, Minde Zhao, Jingmin Wang, Tailing Hu, Xiqi Schuppan, D. |
| description | Background and Aim
Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out a multicenter study to validate the accuracy of LSM in the assessment of liver fibrosis in a large cohort of Chinese patients with chronic hepatitis B (CHB).
Methods
We compared LSM results to histological staging and serum fibrosis markers (five direct markers, APRI and FIB‐4) using Spearman correlation analysis and area under receiver operating characteristic (ROC) curves (AUROCs).
Results
Four hundred sixty‐nine patients were enrolled and eligible for statistical analysis. LSM in F0 to F4 was 5.5 ± 1.7, 5.8 ± 2.2, 7.6 ± 3.4, 14.5 ± 10.8, and 22.3 ± 13.6 kPa, respectively (correlation with fibrosis stage r = 0.522, P 5x the upper limit of normal values had significantly higher stiffness values than stage‐matched patients with normal alanine aminotransferase.
Conclusion
Transient elastography is a reliable noninvasive technique to predict significant liver fibrosis in Chinese patients with CHB, being superior to current biomarker panels. However, enhanced inflammatory activity can lead to elevated stiffness values unrelated to histological fibrosis stage. |
| doi_str_mv | 10.1111/jgh.12840 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1668259437</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1668259437</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3220-7826d704110db6fc125f23ab496b0baa4ebd58d6accbcb763a75b688ace95973</originalsourceid><addsrcrecordid>eNqNkT1vFDEQhi0EIkeg4A8glzSb2Ouv3RJOuQtwgoKTkGgs2zubddgvbB_hav443lxIzTQzmnneKd4XodeUXNBcl7c33QUtK06eoBXlnBRUcfkUrUhFRVEzWp-hFzHeEkI4UeI5OisFE4yIaoX-7IMZo4cxYehNTNNNMHN3xG4aZhOgwWnCEcJhwIMJPyDEZTHng3cJ9_4XBNx6G6boI_YjNlnYTSHhqcXrzo8QAc8mLf8jvvOpw64L0-gd7mDZpyx7_xI9a00f4dVDP0f7zdV-fV3svmw_rN_tCs_KkhSqKmWjCKeUNFa2jpaiLZmxvJaWWGM42EZUjTTOWWeVZEYJK6vKOKhFrdg5ent6O4fp5wFi0oOPDvrejDAdoqZSVqWoOfsvlGefa76gbx7Qgx2g0XPw2amj_mdxBi5PwJ3v4fh4p0Qv2emcnb7PTn_cXt8PWVGcFD4m-P2oyP5rqZgS-tvnrd6I3Vf2XW30J_YXTNOcrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1664440947</pqid></control><display><type>article</type><title>Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jia, Jidong ; Hou, Jinlin ; Ding, Huiguo ; Chen, Guofeng ; Xie, Qing ; Wang, Yuming ; Zeng, Minde ; Zhao, Jingmin ; Wang, Tailing ; Hu, Xiqi ; Schuppan, D.</creator><creatorcontrib>Jia, Jidong ; Hou, Jinlin ; Ding, Huiguo ; Chen, Guofeng ; Xie, Qing ; Wang, Yuming ; Zeng, Minde ; Zhao, Jingmin ; Wang, Tailing ; Hu, Xiqi ; Schuppan, D.</creatorcontrib><description>Background and Aim
Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out a multicenter study to validate the accuracy of LSM in the assessment of liver fibrosis in a large cohort of Chinese patients with chronic hepatitis B (CHB).
Methods
We compared LSM results to histological staging and serum fibrosis markers (five direct markers, APRI and FIB‐4) using Spearman correlation analysis and area under receiver operating characteristic (ROC) curves (AUROCs).
Results
Four hundred sixty‐nine patients were enrolled and eligible for statistical analysis. LSM in F0 to F4 was 5.5 ± 1.7, 5.8 ± 2.2, 7.6 ± 3.4, 14.5 ± 10.8, and 22.3 ± 13.6 kPa, respectively (correlation with fibrosis stage r = 0.522, P < 0.001). AUROC for LSM to correctly allocate patients to histological fibrosis stage ≥ F2, ≥ F3, and F4 was 0.82, 0.88, and 0.90, respectively. LSM outperformed serum fibrosis markers for detection of fibrosis F ≥ 2 and F4. Patients with ALT levels 1–5x and > 5x the upper limit of normal values had significantly higher stiffness values than stage‐matched patients with normal alanine aminotransferase.
Conclusion
Transient elastography is a reliable noninvasive technique to predict significant liver fibrosis in Chinese patients with CHB, being superior to current biomarker panels. However, enhanced inflammatory activity can lead to elevated stiffness values unrelated to histological fibrosis stage.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.12840</identifier><identifier>PMID: 25353058</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Alanine Transaminase - blood ; biomarker ; Biomarkers - blood ; China - epidemiology ; Cohort Studies ; Elasticity Imaging Techniques - methods ; Female ; fibrosis ; Hepatitis B virus ; Hepatitis C virus ; Humans ; Hyaluronic Acid - blood ; inflammation ; Laminin - blood ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - epidemiology ; Male ; Middle Aged ; noninvasive ; Peptide Fragments - blood ; Predictive Value of Tests ; Procollagen - blood ; transient elastography ; Young Adult</subject><ispartof>Journal of gastroenterology and hepatology, 2015-04, Vol.30 (4), p.756-762</ispartof><rights>2015 The Authors Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.12840$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.12840$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25353058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Jidong</creatorcontrib><creatorcontrib>Hou, Jinlin</creatorcontrib><creatorcontrib>Ding, Huiguo</creatorcontrib><creatorcontrib>Chen, Guofeng</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Wang, Yuming</creatorcontrib><creatorcontrib>Zeng, Minde</creatorcontrib><creatorcontrib>Zhao, Jingmin</creatorcontrib><creatorcontrib>Wang, Tailing</creatorcontrib><creatorcontrib>Hu, Xiqi</creatorcontrib><creatorcontrib>Schuppan, D.</creatorcontrib><title>Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out a multicenter study to validate the accuracy of LSM in the assessment of liver fibrosis in a large cohort of Chinese patients with chronic hepatitis B (CHB).
Methods
We compared LSM results to histological staging and serum fibrosis markers (five direct markers, APRI and FIB‐4) using Spearman correlation analysis and area under receiver operating characteristic (ROC) curves (AUROCs).
Results
Four hundred sixty‐nine patients were enrolled and eligible for statistical analysis. LSM in F0 to F4 was 5.5 ± 1.7, 5.8 ± 2.2, 7.6 ± 3.4, 14.5 ± 10.8, and 22.3 ± 13.6 kPa, respectively (correlation with fibrosis stage r = 0.522, P < 0.001). AUROC for LSM to correctly allocate patients to histological fibrosis stage ≥ F2, ≥ F3, and F4 was 0.82, 0.88, and 0.90, respectively. LSM outperformed serum fibrosis markers for detection of fibrosis F ≥ 2 and F4. Patients with ALT levels 1–5x and > 5x the upper limit of normal values had significantly higher stiffness values than stage‐matched patients with normal alanine aminotransferase.
Conclusion
Transient elastography is a reliable noninvasive technique to predict significant liver fibrosis in Chinese patients with CHB, being superior to current biomarker panels. However, enhanced inflammatory activity can lead to elevated stiffness values unrelated to histological fibrosis stage.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>biomarker</subject><subject>Biomarkers - blood</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>fibrosis</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Hyaluronic Acid - blood</subject><subject>inflammation</subject><subject>Laminin - blood</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>noninvasive</subject><subject>Peptide Fragments - blood</subject><subject>Predictive Value of Tests</subject><subject>Procollagen - blood</subject><subject>transient elastography</subject><subject>Young Adult</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqNkT1vFDEQhi0EIkeg4A8glzSb2Ouv3RJOuQtwgoKTkGgs2zubddgvbB_hav443lxIzTQzmnneKd4XodeUXNBcl7c33QUtK06eoBXlnBRUcfkUrUhFRVEzWp-hFzHeEkI4UeI5OisFE4yIaoX-7IMZo4cxYehNTNNNMHN3xG4aZhOgwWnCEcJhwIMJPyDEZTHng3cJ9_4XBNx6G6boI_YjNlnYTSHhqcXrzo8QAc8mLf8jvvOpw64L0-gd7mDZpyx7_xI9a00f4dVDP0f7zdV-fV3svmw_rN_tCs_KkhSqKmWjCKeUNFa2jpaiLZmxvJaWWGM42EZUjTTOWWeVZEYJK6vKOKhFrdg5ent6O4fp5wFi0oOPDvrejDAdoqZSVqWoOfsvlGefa76gbx7Qgx2g0XPw2amj_mdxBi5PwJ3v4fh4p0Qv2emcnb7PTn_cXt8PWVGcFD4m-P2oyP5rqZgS-tvnrd6I3Vf2XW30J_YXTNOcrw</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Jia, Jidong</creator><creator>Hou, Jinlin</creator><creator>Ding, Huiguo</creator><creator>Chen, Guofeng</creator><creator>Xie, Qing</creator><creator>Wang, Yuming</creator><creator>Zeng, Minde</creator><creator>Zhao, Jingmin</creator><creator>Wang, Tailing</creator><creator>Hu, Xiqi</creator><creator>Schuppan, D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201504</creationdate><title>Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B</title><author>Jia, Jidong ; Hou, Jinlin ; Ding, Huiguo ; Chen, Guofeng ; Xie, Qing ; Wang, Yuming ; Zeng, Minde ; Zhao, Jingmin ; Wang, Tailing ; Hu, Xiqi ; Schuppan, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3220-7826d704110db6fc125f23ab496b0baa4ebd58d6accbcb763a75b688ace95973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>biomarker</topic><topic>Biomarkers - blood</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Female</topic><topic>fibrosis</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Hyaluronic Acid - blood</topic><topic>inflammation</topic><topic>Laminin - blood</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>noninvasive</topic><topic>Peptide Fragments - blood</topic><topic>Predictive Value of Tests</topic><topic>Procollagen - blood</topic><topic>transient elastography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Jidong</creatorcontrib><creatorcontrib>Hou, Jinlin</creatorcontrib><creatorcontrib>Ding, Huiguo</creatorcontrib><creatorcontrib>Chen, Guofeng</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Wang, Yuming</creatorcontrib><creatorcontrib>Zeng, Minde</creatorcontrib><creatorcontrib>Zhao, Jingmin</creatorcontrib><creatorcontrib>Wang, Tailing</creatorcontrib><creatorcontrib>Hu, Xiqi</creatorcontrib><creatorcontrib>Schuppan, D.</creatorcontrib><collection>Istex</collection><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Jidong</au><au>Hou, Jinlin</au><au>Ding, Huiguo</au><au>Chen, Guofeng</au><au>Xie, Qing</au><au>Wang, Yuming</au><au>Zeng, Minde</au><au>Zhao, Jingmin</au><au>Wang, Tailing</au><au>Hu, Xiqi</au><au>Schuppan, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>30</volume><issue>4</issue><spage>756</spage><epage>762</epage><pages>756-762</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Liver stiffness measurement (LSM) using transient elastography (FibroScan) is a useful tool to assess fibrosis in various chronic liver diseases. However, studies were mainly performed in Western countries and largely focused on chronic hepatitis C (CHC). We therefore carried out a multicenter study to validate the accuracy of LSM in the assessment of liver fibrosis in a large cohort of Chinese patients with chronic hepatitis B (CHB).
Methods
We compared LSM results to histological staging and serum fibrosis markers (five direct markers, APRI and FIB‐4) using Spearman correlation analysis and area under receiver operating characteristic (ROC) curves (AUROCs).
Results
Four hundred sixty‐nine patients were enrolled and eligible for statistical analysis. LSM in F0 to F4 was 5.5 ± 1.7, 5.8 ± 2.2, 7.6 ± 3.4, 14.5 ± 10.8, and 22.3 ± 13.6 kPa, respectively (correlation with fibrosis stage r = 0.522, P < 0.001). AUROC for LSM to correctly allocate patients to histological fibrosis stage ≥ F2, ≥ F3, and F4 was 0.82, 0.88, and 0.90, respectively. LSM outperformed serum fibrosis markers for detection of fibrosis F ≥ 2 and F4. Patients with ALT levels 1–5x and > 5x the upper limit of normal values had significantly higher stiffness values than stage‐matched patients with normal alanine aminotransferase.
Conclusion
Transient elastography is a reliable noninvasive technique to predict significant liver fibrosis in Chinese patients with CHB, being superior to current biomarker panels. However, enhanced inflammatory activity can lead to elevated stiffness values unrelated to histological fibrosis stage.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25353058</pmid><doi>10.1111/jgh.12840</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2015-04, Vol.30 (4), p.756-762 |
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| subjects | Adult Alanine Transaminase - blood biomarker Biomarkers - blood China - epidemiology Cohort Studies Elasticity Imaging Techniques - methods Female fibrosis Hepatitis B virus Hepatitis C virus Humans Hyaluronic Acid - blood inflammation Laminin - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - epidemiology Male Middle Aged noninvasive Peptide Fragments - blood Predictive Value of Tests Procollagen - blood transient elastography Young Adult |
| title | Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B |
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