Hydrolyzed polyacrylamide grafted carboxymethylxyloglucan based microbeads for pH responsive drug delivery
•Carboxymethylxyloglucan based new material for pharmaceutical application was synthesized and characterized.•Acute oral toxicity study ensured the bio-safety of developed copolymer.•Drug loaded pH responsive microbeads were developed and evaluated.•Effect of process parameters on overall performanc...
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| Veröffentlicht in: | International journal of biological macromolecules 2014-06, Vol.67, p.28-36 |
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| container_title | International journal of biological macromolecules |
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| creator | Setty, C. Mallikarjuna Deshmukh, Anand S. Badiger, Aravind M. |
| description | •Carboxymethylxyloglucan based new material for pharmaceutical application was synthesized and characterized.•Acute oral toxicity study ensured the bio-safety of developed copolymer.•Drug loaded pH responsive microbeads were developed and evaluated.•Effect of process parameters on overall performance of microbeads was correlated.
The present study investigates the pharmaceutical application of hydrolyzed polyacrylamide grafted carboxymethylxyloglucan (HPam-g-CMXG), as promising polymeric material for the development of pH responsive microbeads. The graft copolymer was synthesized by conventional free radical polymerization method and saponified to enhance its functionality and characterized. An acute oral toxicity study ensured the bio-safety of developed copolymer for clinical application. Various batches of pH responsive spherical microbeads were developed and evaluated for the effect of process parameters on their overall performance. Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations. Both the drug release and swelling of microbeads were significantly higher in simulated intestinal (alkaline) pH compared to simulated gastric (acidic) pH and this nature is desirable for targeted drug delivery. A strong correlation was observed between the process parameters and matrix composition and it directly influenced the drug transport mechanism. In conclusion, the hydrolyzed polyacrylamide grafted carboxymethylxyloglucan holds an immense potential to be explored pharmaceutically as new matrix material for the design of targeted drug delivery system. |
| doi_str_mv | 10.1016/j.ijbiomac.2014.03.005 |
| format | Article |
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The present study investigates the pharmaceutical application of hydrolyzed polyacrylamide grafted carboxymethylxyloglucan (HPam-g-CMXG), as promising polymeric material for the development of pH responsive microbeads. The graft copolymer was synthesized by conventional free radical polymerization method and saponified to enhance its functionality and characterized. An acute oral toxicity study ensured the bio-safety of developed copolymer for clinical application. Various batches of pH responsive spherical microbeads were developed and evaluated for the effect of process parameters on their overall performance. Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations. Both the drug release and swelling of microbeads were significantly higher in simulated intestinal (alkaline) pH compared to simulated gastric (acidic) pH and this nature is desirable for targeted drug delivery. A strong correlation was observed between the process parameters and matrix composition and it directly influenced the drug transport mechanism. In conclusion, the hydrolyzed polyacrylamide grafted carboxymethylxyloglucan holds an immense potential to be explored pharmaceutically as new matrix material for the design of targeted drug delivery system.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2014.03.005</identifier><identifier>PMID: 24632345</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acrylic Resins - chemistry ; Chemistry, Pharmaceutical ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Microbeads ; Microspheres ; pH responsive ; Polyacrylamide grafted carboxymethylxyloglucan ; Polymers - chemistry</subject><ispartof>International journal of biological macromolecules, 2014-06, Vol.67, p.28-36</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-e2b0fe6614d2db1e59a8c1d7a98653d14d28b84433dd4594beec34433528eb343</citedby><cites>FETCH-LOGICAL-c401t-e2b0fe6614d2db1e59a8c1d7a98653d14d28b84433dd4594beec34433528eb343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2014.03.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24632345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Setty, C. Mallikarjuna</creatorcontrib><creatorcontrib>Deshmukh, Anand S.</creatorcontrib><creatorcontrib>Badiger, Aravind M.</creatorcontrib><title>Hydrolyzed polyacrylamide grafted carboxymethylxyloglucan based microbeads for pH responsive drug delivery</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>•Carboxymethylxyloglucan based new material for pharmaceutical application was synthesized and characterized.•Acute oral toxicity study ensured the bio-safety of developed copolymer.•Drug loaded pH responsive microbeads were developed and evaluated.•Effect of process parameters on overall performance of microbeads was correlated.
The present study investigates the pharmaceutical application of hydrolyzed polyacrylamide grafted carboxymethylxyloglucan (HPam-g-CMXG), as promising polymeric material for the development of pH responsive microbeads. The graft copolymer was synthesized by conventional free radical polymerization method and saponified to enhance its functionality and characterized. An acute oral toxicity study ensured the bio-safety of developed copolymer for clinical application. Various batches of pH responsive spherical microbeads were developed and evaluated for the effect of process parameters on their overall performance. Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations. Both the drug release and swelling of microbeads were significantly higher in simulated intestinal (alkaline) pH compared to simulated gastric (acidic) pH and this nature is desirable for targeted drug delivery. A strong correlation was observed between the process parameters and matrix composition and it directly influenced the drug transport mechanism. In conclusion, the hydrolyzed polyacrylamide grafted carboxymethylxyloglucan holds an immense potential to be explored pharmaceutically as new matrix material for the design of targeted drug delivery system.</description><subject>Acrylic Resins - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrolysis</subject><subject>Microbeads</subject><subject>Microspheres</subject><subject>pH responsive</subject><subject>Polyacrylamide grafted carboxymethylxyloglucan</subject><subject>Polymers - chemistry</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KVBbav4By7CXBjj9wbiBEu0hIXMrZ8sdk68hZp3aCCL--Xi30ymlm3nlnRvMgdElwQzARV0PjB-PjqG3TYsIaTBuM-Re0IfK6qzHG9ARtSoPUklB8hs5zHooqOJFf0VnLBG0p4xs0bFeXYljfwFVTidqmNejRO6h2Sfdzka1OJr6uI8x_1vC6hrgLi9X7yuhcuqO3KRrQLld9TNW0rRLkKe6zf4HKpWVXOQglT-s3dNrrkOH7e7xAzz_vf99t68enXw93t4-1ZZjMNbQG9yAEYa51hgDvtLTEXetOCk7dQZZGMkapc4x3zABYeih5K8FQRi_Qj-PeKcW_C-RZjT5bCEHvIS5ZESFkyzvCSbGKo7X8kHOCXk3JjzqtimB14KwG9cFZHTgrTFXhXAYv328sZgT3f-wDbDHcHA1QPn3xkFS2HvYWnE9gZ-Wi_-zGP_HDlLE</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Setty, C. 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Mallikarjuna</creatorcontrib><creatorcontrib>Deshmukh, Anand S.</creatorcontrib><creatorcontrib>Badiger, Aravind M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Setty, C. 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The present study investigates the pharmaceutical application of hydrolyzed polyacrylamide grafted carboxymethylxyloglucan (HPam-g-CMXG), as promising polymeric material for the development of pH responsive microbeads. The graft copolymer was synthesized by conventional free radical polymerization method and saponified to enhance its functionality and characterized. An acute oral toxicity study ensured the bio-safety of developed copolymer for clinical application. Various batches of pH responsive spherical microbeads were developed and evaluated for the effect of process parameters on their overall performance. Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations. Both the drug release and swelling of microbeads were significantly higher in simulated intestinal (alkaline) pH compared to simulated gastric (acidic) pH and this nature is desirable for targeted drug delivery. A strong correlation was observed between the process parameters and matrix composition and it directly influenced the drug transport mechanism. In conclusion, the hydrolyzed polyacrylamide grafted carboxymethylxyloglucan holds an immense potential to be explored pharmaceutically as new matrix material for the design of targeted drug delivery system.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24632345</pmid><doi>10.1016/j.ijbiomac.2014.03.005</doi><tpages>9</tpages></addata></record> |
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| subjects | Acrylic Resins - chemistry Chemistry, Pharmaceutical Drug Delivery Systems Drug Liberation Humans Hydrogen-Ion Concentration Hydrolysis Microbeads Microspheres pH responsive Polyacrylamide grafted carboxymethylxyloglucan Polymers - chemistry |
| title | Hydrolyzed polyacrylamide grafted carboxymethylxyloglucan based microbeads for pH responsive drug delivery |
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