Enigma homolog 1 promotes myogenic gene expression and differentiation of C2C12 cells

•The roles of ENH splicing variants in C2C12 differentiation are examined.•PDZ- and LIM-containing ENH1 is essential for myogenic differentiation.•LIM-less ENHs disrupts morphological transformation.•Development switch from ENH1 to LIM-less ENHs ensures normal differentiation. The Enigma homolog (EN...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-06, Vol.435 (3), p.483-487
Hauptverfasser:	Ito, Jumpei, Takita, Masatoshi, Takimoto, Koichi, Maturana, Andrés D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Adenovirus Animals C2C12 myoblast Cell Differentiation - genetics Cell Line, Tumor Gene Expression Regulation, Neoplastic Mice Microfilament Proteins - antagonists & inhibitors Microfilament Proteins - genetics Microfilament Proteins - physiology Muscle Development - genetics Muscle differentiation Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism MyoD Protein - genetics Protein Interaction Mapping RNA Interference Scaffolding protein
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