The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7

The canonical transient receptor potential channel subfamily (TRPC3, TRPC6, and TRPC7) contains Ca(2+) permeable non-selective cation channels that are widely expressed in a variety of tissues. There is increasing evidence implicating TRPC channels, particularly TRPC3 and 6, in physiological and pat...

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Veröffentlicht in:	Assay and drug development technologies 2014-06, Vol.12 (5), p.282-292
Hauptverfasser:	McPate, Mark, Bhalay, Gurdip, Beckett, Martin, Fairbrother, Sian, Gosling, Martin, Groot-Kormelink, Paul J, Lane, Rebecca, Kent, Toby, Van Diepen, Michiel T, Tranter, Pamela, Verkuyl, J Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Automation Cells, Cultured CHO Cells Cricetulus High-Throughput Screening Assays Humans Kinetics Patch-Clamp Techniques - methods TRPC Cation Channels - antagonists & inhibitors TRPC Cation Channels - metabolism TRPC6 Cation Channel
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