Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses

•Broad-spectrum antivirals can effectively control influenza burdens.•Aronia exhibited virucidal activity against various influenza viruses.•Mainly acting on the HA protein, Aronia inhibited influenza virus replication.•Aronia’s components, ellagic acid and myricetin, saved mice from influenza chall...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-10, Vol.440 (1), p.14-19
Hauptverfasser:	Park, Sehee, Kim, Jin Il, Lee, Ilseob, Lee, Sangmoo, Hwang, Min-Woong, Bae, Joon-Yong, Heo, Jun, Kim, Donghwan, Han, Sang-Zin, Park, Man-Seong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - therapeutic use Aronia Aronia melanocarpa Cell Line Drug Resistance, Viral Ellagic Acid - chemistry Ellagic Acid - isolation & purification Ellagic Acid - therapeutic use Female Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - therapeutic use Fruit - chemistry Humans Influenza A virus - drug effects Influenza A virus - physiology Influenza A Virus, H5N1 Subtype - drug effects Influenza A Virus, H5N1 Subtype - physiology Influenza virus Influenza, Human - drug therapy Mice Mice, Inbred BALB C Orthomyxoviridae Infections - drug therapy Oseltamivir - pharmacology Photinia - chemistry Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - therapeutic use Polyphenol Polyphenols - chemistry Polyphenols - isolation & purification Polyphenols - therapeutic use Therapeutics Virus Replication - drug effects
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