Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina
Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papi...
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| Veröffentlicht in: | Indian journal of medical microbiology 2013-04, Vol.31 (2), p.138-141 |
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| creator | Deluca, GD Marín, HM Blanco, NS Basiletti, JA González, JV Merino, AL Picconi, MA |
| description | Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program. |
| doi_str_mv | 10.4103/0255-0857.115228 |
| format | Article |
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Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.</description><identifier>ISSN: 0255-0857</identifier><identifier>EISSN: 1998-3646</identifier><identifier>DOI: 10.4103/0255-0857.115228</identifier><identifier>PMID: 23867669</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Argentina - epidemiology ; ASCUS ; Cervical cancer ; cervical infection ; DNA, Viral - genetics ; Female ; Genotype ; HG-SIL ; HPV ; Human papillomavirus ; Humans ; Immunization ; LG-SIL ; Middle Aged ; Molecular Epidemiology ; Mortality ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - virology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Prevalence ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - virology ; Vaccines ; Young Adult</subject><ispartof>Indian journal of medical microbiology, 2013-04, Vol.31 (2), p.138-141</ispartof><rights>2013 Indian Journal of Medical Microbiology</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Apr-Jun 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1427311505?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,27907,27908,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23867669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deluca, GD</creatorcontrib><creatorcontrib>Marín, HM</creatorcontrib><creatorcontrib>Blanco, NS</creatorcontrib><creatorcontrib>Basiletti, JA</creatorcontrib><creatorcontrib>González, JV</creatorcontrib><creatorcontrib>Merino, AL</creatorcontrib><creatorcontrib>Picconi, MA</creatorcontrib><title>Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina</title><title>Indian journal of medical microbiology</title><addtitle>Indian J Med Microbiol</addtitle><description>Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Argentina - epidemiology</subject><subject>ASCUS</subject><subject>Cervical cancer</subject><subject>cervical infection</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>HG-SIL</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunization</subject><subject>LG-SIL</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Mortality</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Papillomavirus Infections - virology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prevalence</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0255-0857</issn><issn>1998-3646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1vFSEUhonR2Gt178qQuHEzFYaPAXdt_WrSpJu6JgxzxtLOwAjDvem_Lze3bdQNhJznvCHPi9B7Sk44JewzaYVoiBLdCaWibdULtKFaq4ZJLl-izfP4CL3J-ZbUN9f8NTpqmZKdlHqDxq8-r8n3ZfUx4DjimzLbgBe7-GmKs936VDL-DSGu9wtk7APexRnq6dcb7CBtvbMTttMKye4zMh5TnHGIqc5PU91cfbBv0avRThnePd7H6Nf3b9fnP5vLqx8X56eXDTDVloZzookbJRGqG_QIIx_B9ZJK1w3MsXbUVPWOA2O6h4FVB1woLrgVlna81-wYfTrkLin-KZBXM_vsYJpsgFiyoVKqVnSd5hX9-B96G0sK9XeG8rZj1SgRlfrwSJV-hsEsyc823ZsngxU4OwC7uHeQ76ayg2QqexfizlBi9k2Z5yrMoSlDmTJP7mvIl0MIVDdbX_ez8xAcDD6BW80Q_T9J5q8k9gCgpJuz</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Deluca, GD</creator><creator>Marín, HM</creator><creator>Blanco, NS</creator><creator>Basiletti, JA</creator><creator>González, JV</creator><creator>Merino, AL</creator><creator>Picconi, MA</creator><general>Elsevier B.V</general><general>Medknow Publications</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T2</scope><scope>7U2</scope></search><sort><creationdate>20130401</creationdate><title>Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina</title><author>Deluca, GD ; Marín, HM ; Blanco, NS ; Basiletti, JA ; González, JV ; Merino, AL ; Picconi, MA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e382u-44090cf60587d9fef4fecb616c7d3c32f918bc4e339bed3410458454a5a174b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Argentina - epidemiology</topic><topic>ASCUS</topic><topic>Cervical cancer</topic><topic>cervical infection</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>HG-SIL</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Immunization</topic><topic>LG-SIL</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Mortality</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Papillomavirus Infections - virology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prevalence</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deluca, GD</creatorcontrib><creatorcontrib>Marín, HM</creatorcontrib><creatorcontrib>Blanco, NS</creatorcontrib><creatorcontrib>Basiletti, JA</creatorcontrib><creatorcontrib>González, JV</creatorcontrib><creatorcontrib>Merino, AL</creatorcontrib><creatorcontrib>Picconi, MA</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><jtitle>Indian journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deluca, GD</au><au>Marín, HM</au><au>Blanco, NS</au><au>Basiletti, JA</au><au>González, JV</au><au>Merino, AL</au><au>Picconi, MA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina</atitle><jtitle>Indian journal of medical microbiology</jtitle><addtitle>Indian J Med Microbiol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>31</volume><issue>2</issue><spage>138</spage><epage>141</epage><pages>138-141</pages><issn>0255-0857</issn><eissn>1998-3646</eissn><abstract>Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>23867669</pmid><doi>10.4103/0255-0857.115228</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Argentina - epidemiology ASCUS Cervical cancer cervical infection DNA, Viral - genetics Female Genotype HG-SIL HPV Human papillomavirus Humans Immunization LG-SIL Middle Aged Molecular Epidemiology Mortality Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Papillomavirus Infections - virology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Prevalence Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - virology Vaccines Young Adult |
| title | Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina |
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