Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction

A newly identified secreted protein, MYDGF, acts on cardiac muscle and endothelial cells to protect and repair the heart after myocardial infarction. Paracrine-acting proteins are emerging as a central mechanism by which bone marrow cell–based therapies improve tissue repair and heart function after...

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Veröffentlicht in:	Nature medicine 2015-02, Vol.21 (2), p.140-149
Hauptverfasser:	Korf-Klingebiel, Mortimer, Reboll, Marc R, Klede, Stefanie, Brod, Torben, Pich, Andreas, Polten, Felix, Napp, L Christian, Bauersachs, Johann, Ganser, Arnold, Brinkmann, Eva, Reimann, Ines, Kempf, Tibor, Niessen, Hans W, Mizrahi, Jacques, Schönfeld, Hans-Joachim, Iglesias, Antonio, Bobadilla, Maria, Wang, Yong, Wollert, Kai C
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/21 13/51 38 64/110 692/308/575 692/699/75/2/1674 82 82/47 Animals Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - metabolism Cancer Research Cardiovascular disease Care and treatment Cell Proliferation - drug effects Cell Proliferation - genetics Cellular therapy Clinical trials Endothelial Cells - drug effects Genetic aspects Growth factors Health aspects Heart attack HEK293 Cells Humans Infectious Diseases Interleukins - genetics Interleukins - metabolism Interleukins - pharmacology Macrophages - metabolism Medical research Medicine, Experimental Metabolic Diseases Mice Mice, Knockout Molecular Medicine Monocytes - metabolism Myocardial infarction Myocardial Infarction - metabolism Myocardial Reperfusion Injury - metabolism Myocytes, Cardiac Neovascularization, Physiologic Neurosciences Proteins Therapy Tissue engineering Tissues Ventricular Remodeling - drug effects Ventricular Remodeling - genetics
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