Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction

A newly identified secreted protein, MYDGF, acts on cardiac muscle and endothelial cells to protect and repair the heart after myocardial infarction. Paracrine-acting proteins are emerging as a central mechanism by which bone marrow cell–based therapies improve tissue repair and heart function after...

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Veröffentlicht in:	Nature medicine 2015-02, Vol.21 (2), p.140-149
Hauptverfasser:	Korf-Klingebiel, Mortimer, Reboll, Marc R, Klede, Stefanie, Brod, Torben, Pich, Andreas, Polten, Felix, Napp, L Christian, Bauersachs, Johann, Ganser, Arnold, Brinkmann, Eva, Reimann, Ines, Kempf, Tibor, Niessen, Hans W, Mizrahi, Jacques, Schönfeld, Hans-Joachim, Iglesias, Antonio, Bobadilla, Maria, Wang, Yong, Wollert, Kai C
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/21 13/51 38 64/110 692/308/575 692/699/75/2/1674 82 82/47 Animals Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - metabolism Cancer Research Cardiovascular disease Care and treatment Cell Proliferation - drug effects Cell Proliferation - genetics Cellular therapy Clinical trials Endothelial Cells - drug effects Genetic aspects Growth factors Health aspects Heart attack HEK293 Cells Humans Infectious Diseases Interleukins - genetics Interleukins - metabolism Interleukins - pharmacology Macrophages - metabolism Medical research Medicine, Experimental Metabolic Diseases Mice Mice, Knockout Molecular Medicine Monocytes - metabolism Myocardial infarction Myocardial Infarction - metabolism Myocardial Reperfusion Injury - metabolism Myocytes, Cardiac Neovascularization, Physiologic Neurosciences Proteins Therapy Tissue engineering Tissues Ventricular Remodeling - drug effects Ventricular Remodeling - genetics
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creator	Korf-Klingebiel, Mortimer Reboll, Marc R Klede, Stefanie Brod, Torben Pich, Andreas Polten, Felix Napp, L Christian Bauersachs, Johann Ganser, Arnold Brinkmann, Eva Reimann, Ines Kempf, Tibor Niessen, Hans W Mizrahi, Jacques Schönfeld, Hans-Joachim Iglesias, Antonio Bobadilla, Maria Wang, Yong Wollert, Kai C
description	A newly identified secreted protein, MYDGF, acts on cardiac muscle and endothelial cells to protect and repair the heart after myocardial infarction. Paracrine-acting proteins are emerging as a central mechanism by which bone marrow cell–based therapies improve tissue repair and heart function after myocardial infarction (MI). We carried out a bioinformatic secretome analysis in bone marrow cells from patients with acute MI to identify novel secreted proteins with therapeutic potential. Functional screens revealed a secreted protein encoded by an open reading frame on chromosome 19 ( C19orf10 ) that promotes cardiac myocyte survival and angiogenesis. We show that bone marrow–derived monocytes and macrophages produce this protein endogenously to protect and repair the heart after MI, and we named it myeloid-derived growth factor (MYDGF). Whereas Mydgf -deficient mice develop larger infarct scars and more severe contractile dysfunction compared to wild-type mice, treatment with recombinant Mydgf reduces scar size and contractile dysfunction after MI. This study is the first to assign a biological function to MYDGF, and it may serve as a prototypical example for the development of protein-based therapies for ischemic tissue repair.
doi_str_mv	10.1038/nm.3778
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subjects	13/106 13/21 13/51 38 64/110 692/308/575 692/699/75/2/1674 82 82/47 Animals Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - metabolism Cancer Research Cardiovascular disease Care and treatment Cell Proliferation - drug effects Cell Proliferation - genetics Cellular therapy Clinical trials Endothelial Cells - drug effects Genetic aspects Growth factors Health aspects Heart attack HEK293 Cells Humans Infectious Diseases Interleukins - genetics Interleukins - metabolism Interleukins - pharmacology Macrophages - metabolism Medical research Medicine, Experimental Metabolic Diseases Mice Mice, Knockout Molecular Medicine Monocytes - metabolism Myocardial infarction Myocardial Infarction - metabolism Myocardial Reperfusion Injury - metabolism Myocytes, Cardiac Neovascularization, Physiologic Neurosciences Proteins Therapy Tissue engineering Tissues Ventricular Remodeling - drug effects Ventricular Remodeling - genetics
title	Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T00%3A59%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Myeloid-derived%20growth%20factor%20(C19orf10)%20mediates%20cardiac%20repair%20following%20myocardial%20infarction&rft.jtitle=Nature%20medicine&rft.au=Korf-Klingebiel,%20Mortimer&rft.date=2015-02-01&rft.volume=21&rft.issue=2&rft.spage=140&rft.epage=149&rft.pages=140-149&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm.3778&rft_dat=%3Cgale_proqu%3EA401380634%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1651533915&rft_id=info:pmid/25581518&rft_galeid=A401380634&rfr_iscdi=true