Loss of SH3 Domain–Binding Protein 2 Function Suppresses Bone Destruction in Tumor Necrosis Factor–Driven and Collagen‐Induced Arthritis in Mice

Objective SH3 domain–binding protein 2 (SH3BP2) is a signaling adapter protein that regulates the immune and skeletal systems. The present study was undertaken to investigate the role of SH3BP2 in arthritis using 2 experimental mouse models, i.e., human tumor necrosis factor α–transgenic (hTNF‐Tg) m...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2015-03, Vol.67 (3), p.656-667
Hauptverfasser:	Mukai, Tomoyuki, Gallant, Richard, Ishida, Shu, Kittaka, Mizuho, Yoshitaka, Teruhito, Fox, David A., Morita, Yoshitaka, Nishida, Keiichiro, Rottapel, Robert, Ueki, Yasuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor Proteins, Signal Transducing - physiology Animals Arthritis Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Autoantibodies - blood Blotting, Western Bone Resorption - metabolism Bone Resorption - pathology Bone Resorption - prevention & control Collagen Collagen Type II - immunology Enzyme-Linked Immunosorbent Assay Gangrene Humans Medical research Mice Mice, Inbred C57BL Mice, Transgenic NFATC Transcription Factors - metabolism Osteoclasts - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Rodents Tumor Necrosis Factor-alpha - genetics X-Ray Microtomography
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