Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

Membrane sorting of Ras and its isolated lipid anchor is based on membrane curvature, sensed by Ras itself. This helps to explain the previous inability to match in vivo results in vitro in promoting the raftophilic Ras to partition with membrane lipid rafts. Trafficking and sorting of membrane-anch...

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Veröffentlicht in:	Nature chemical biology 2015-03, Vol.11 (3), p.192-194
Hauptverfasser:	Larsen, Jannik Bruun, Jensen, Martin Borch, Bhatia, Vikram K, Pedersen, Søren L, Bjørnholm, Thomas, Iversen, Lars, Uline, Mark, Szleifer, Igal, Jensen, Knud J, Hatzakis, Nikos S, Stamou, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	631/57 631/80/313 631/92/314 96/35 96/63 Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Cell Biology Chemistry Chemistry/Food Science Lipid Bilayers Liposomes - chemistry Membrane Lipids - chemistry Membrane Microdomains - chemistry Membranes Membranes - chemistry Membranes - ultrastructure Monomeric GTP-Binding Proteins - chemistry Palmitic Acid - chemistry Phosphatidylcholines - chemistry
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