Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression
UVB irradiation (290–320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epiderma...
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| Veröffentlicht in: | Journal of investigative dermatology 2015-01, Vol.135 (1), p.222-228 |
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| creator | Meulenbroeks, Chantal van Weelden, Huib Schwartz, Christian Voehringer, David Redegeld, Frank A.M. Rutten, Victor P.M.G. Willemse, Ton Sijts, Alice J.A.M. Zaiss, Dietmar M.W. |
| description | UVB irradiation (290–320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell–derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell–mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin. |
| doi_str_mv | 10.1038/jid.2014.329 |
| format | Article |
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Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell–derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell–mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.2014.329</identifier><identifier>PMID: 25089660</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amphiregulin ; Animals ; Basophils - immunology ; Basophils - metabolism ; Basophils - radiation effects ; Dermatitis, Contact - immunology ; Dermatitis, Contact - radiotherapy ; Disease Models, Animal ; EGF Family of Proteins - genetics ; EGF Family of Proteins - immunology ; EGF Family of Proteins - metabolism ; Female ; Immune Tolerance - immunology ; Immune Tolerance - radiation effects ; Male ; Mast Cells - immunology ; Mast Cells - metabolism ; Mast Cells - radiation effects ; Mice, Inbred C57BL ; Mice, Knockout ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; T-Lymphocytes, Regulatory - radiation effects ; Ultraviolet Therapy</subject><ispartof>Journal of investigative dermatology, 2015-01, Vol.135 (1), p.222-228</ispartof><rights>2015 The Society for Investigative Dermatology, Inc</rights><rights>Copyright Nature Publishing Group Jan 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-84f015debd3d151465eb1b337295411d3cb555f216bf48f07a942e9a41f912593</citedby><cites>FETCH-LOGICAL-c507t-84f015debd3d151465eb1b337295411d3cb555f216bf48f07a942e9a41f912593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1635245303?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25089660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meulenbroeks, Chantal</creatorcontrib><creatorcontrib>van Weelden, Huib</creatorcontrib><creatorcontrib>Schwartz, Christian</creatorcontrib><creatorcontrib>Voehringer, David</creatorcontrib><creatorcontrib>Redegeld, Frank A.M.</creatorcontrib><creatorcontrib>Rutten, Victor P.M.G.</creatorcontrib><creatorcontrib>Willemse, Ton</creatorcontrib><creatorcontrib>Sijts, Alice J.A.M.</creatorcontrib><creatorcontrib>Zaiss, Dietmar M.W.</creatorcontrib><title>Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>UVB irradiation (290–320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. 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Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin.</description><subject>Amphiregulin</subject><subject>Animals</subject><subject>Basophils - immunology</subject><subject>Basophils - metabolism</subject><subject>Basophils - radiation effects</subject><subject>Dermatitis, Contact - immunology</subject><subject>Dermatitis, Contact - radiotherapy</subject><subject>Disease Models, Animal</subject><subject>EGF Family of Proteins - genetics</subject><subject>EGF Family of Proteins - immunology</subject><subject>EGF Family of Proteins - metabolism</subject><subject>Female</subject><subject>Immune Tolerance - immunology</subject><subject>Immune Tolerance - radiation effects</subject><subject>Male</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - metabolism</subject><subject>Mast Cells - radiation effects</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>T-Lymphocytes, Regulatory - radiation effects</subject><subject>Ultraviolet Therapy</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkbtuFTEQhi0UlBxCOmq0Eg0Fe_DYnr2USQhkpUgUSRASheVdzwYf7Q17NxId78Ab5knw0UlSRBSpRqP55pdmPsbeAF8Dl8XHjbNrwUGtpShfsBWgkCnkKt9jK86FSAUX3w_YqxA2nEOmsNhnBwJ5UWYZX7EfJyaM00_XpZ_Iu1uyyXEfW083S-eGpArJWQg0zM50STv65PrbSVJ5b6wzsxuHuz9_q8EuTdyr-n4ZKLlcpslTCHH4mr1sTRfo6L4esuvPZ1en5-nF1y_V6fFF2iDP57RQLQe0VFtpAUFlSDXUUuaiRAVgZVMjYisgq1tVtDw3pRJUGgVtCQJLecje73InP_5aKMy6d6GhrjMDjUvQkGWFQBRF8QxU5hhxuU199wTdjIsf4iFbCoVCyWWkPuyoxo8heGr15F1v_G8NXG_96OhHb_3o6Cfib-9Dl7on-wg_CIlAtgMoPuzWkdehcTTEB0cnzazt6P6f_A9iqZzV</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Meulenbroeks, Chantal</creator><creator>van Weelden, Huib</creator><creator>Schwartz, Christian</creator><creator>Voehringer, David</creator><creator>Redegeld, Frank A.M.</creator><creator>Rutten, Victor P.M.G.</creator><creator>Willemse, Ton</creator><creator>Sijts, Alice J.A.M.</creator><creator>Zaiss, Dietmar M.W.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression</title><author>Meulenbroeks, Chantal ; 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Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell–derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell–mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25089660</pmid><doi>10.1038/jid.2014.329</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amphiregulin Animals Basophils - immunology Basophils - metabolism Basophils - radiation effects Dermatitis, Contact - immunology Dermatitis, Contact - radiotherapy Disease Models, Animal EGF Family of Proteins - genetics EGF Family of Proteins - immunology EGF Family of Proteins - metabolism Female Immune Tolerance - immunology Immune Tolerance - radiation effects Male Mast Cells - immunology Mast Cells - metabolism Mast Cells - radiation effects Mice, Inbred C57BL Mice, Knockout T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - radiation effects Ultraviolet Therapy |
| title | Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression |
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