Chromosome 12 long arm rearrangement covering MDM2 and RASAL1 is associated with aggressive craniofacial juvenile ossifying fibroma and extracranial psammomatoid fibro-osseous lesions

To evaluate the diagnostic value of MDM2 status in craniofacial fibro-osseous lesions, we investigated MDM2 expression by immunohistochemistry and analyzed MDM2 amplification by qPCR in 30 cases of ossifying fibroma (including 13 cases of the juvenile variant) and 17 cases of fibrous dysplasia. Two...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Modern pathology 2015-01, Vol.28 (1), p.48-56
Hauptverfasser:	Tabareau-Delalande, Flore, Collin, Christine, Gomez-Brouchet, Anne, Bouvier, Corinne, Decouvelaere, Anne-Valérie, de Muret, Anne, Pagès, Jean-Christophe, de Pinieux, Gonzague
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2421 692/699/67/1344 Adolescent Adult Aged Bone Neoplasms - diagnosis Bone Neoplasms - genetics Child Child, Preschool Chromosomes, Human, Pair 12 - genetics Facial Bones Female Fibroma, Ossifying - diagnosis Fibroma, Ossifying - genetics Fibrous Dysplasia of Bone - diagnosis Fibrous Dysplasia of Bone - genetics Gene Rearrangement GTPase-Activating Proteins - genetics Humans Immunohistochemistry Infant Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged original-article Pathology Polymerase Chain Reaction Proto-Oncogene Proteins c-mdm2 - genetics Retrospective Studies Skull Skull Neoplasms - diagnosis Skull Neoplasms - genetics Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!