The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes

PINK1 (phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced kinase 1), a Parkinson’s disease-associated gene, was identified originally because of its induction by the tumor-suppressor PTEN. PINK1 promotes cell survival and potentially metastatic functions and protects against cell...

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Veröffentlicht in:	Oncogene 2015-03, Vol.34 (11), p.1363-1374
Hauptverfasser:	O'Flanagan, C H, Morais, V A, Wurst, W, De Strooper, B, O'Neill, C
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/755 692/699/67 Animals Apoptosis Cancer Cell Biology Cell cycle Cell division Cell Division - genetics Cell Line, Tumor Cell Movement Cell proliferation Cell Proliferation - genetics Cell survival Cellular biology Chemotherapy Chromosome 10 Clonal deletion Cyclin D1 Cyclin D1 - biosynthesis Cytokinesis Cytokinesis - genetics Dynamin Ectopic expression Embryo fibroblasts Embryos Gene Expression Regulation, Neoplastic - genetics Genetic aspects Genotype & phenotype GTP Phosphohydrolases - metabolism HeLa Cells Human Genetics Humans Internal Medicine Invasiveness Kinases M Phase Cell Cycle Checkpoints - genetics MCF-7 Cells Medicine Medicine & Public Health Metastases Mice Mice, Knockout Microtubule-Associated Proteins - metabolism Mitochondria Mitochondria - genetics Mitochondria - pathology Mitochondrial Proteins - metabolism Mitosis Movement disorders Neoplasm Invasiveness - genetics Neurodegenerative diseases Nocodazole Oncology original-article Parkinson Disease - genetics Parkinson's disease Phenotypes Protein Kinases - biosynthesis Protein Kinases - genetics Protein Kinases - metabolism PTEN protein Ribonucleic acid Risk factors RNA RNA Interference RNA, Small Interfering
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