Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome
Background Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (L...
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| Veröffentlicht in: | Lupus 2015-02, Vol.24 (2), p.186-190 |
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| creator | Khogeer, H Alfattani, A Al Kaff, M Al shehri, T Khojah, O Owaidah, T |
| description | Background
Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (LA), anti-beta2 glycoprotein I (aβ2GPI) and anticardiolipin (aCL). The clinical significance of other antibodies like anti-phosphatidylserine antibodies (aPS) is still under investigation.
Objectives
The aim of the study was to assess the diagnostic value of aPS antibodies, and to compare their utility to that of other aPL antibodies.
Methods
We conducted a prospective observational study consisting of 212 patients with suspected thrombosis, pregnancy failure, or unexplained, prolonged clotting time. Data on demography, clinical presentation and autoantibody levels were assessed. Descriptive analysis, accuracy analysis, sensitivity, specificity, predictive value and likelihood ratio were calculated for aPS in comparison to other aPL.
Results
The diagnostic value of aPS versus other aPL antibodies revealed the high specificity of aPS (87%), with 70% of aPS-positive patients being confirmed APS. When the aPS test was used as a single test, it was effective for detection of confirmed APS cases (p |
| doi_str_mv | 10.1177/0961203314552462 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1668252048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203314552462</sage_id><sourcerecordid>1652403676</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-54734e39728e436ee6fbd822310381a829c96e35619c419ac114b2cedbec2aaf3</originalsourceid><addsrcrecordid>eNqNkc1LxDAQxYMo7rp69yQFL16q-WraHpfFL1jwongsaTLdzdI2NWkP-9-btavIguBpYOb33mTyELok-JaQNL3DuSAUM0Z4klAu6BGaEp6mcejTYzTdjePdfILOvN9gjBnJxSma0IQmLEnJFL3P2950a-u7teyN3tYenGkhkqFdWm3AR9JH2shVa31vVGRabZTsrfORrb6wUW1r0xkd-W2rnW3gHJ1UMphd7OsMvT3cvy6e4uXL4_NivowVy7M-TnjKOLA8pRlwJgBEVeqMUkYwy4jMaK5yASwRJFec5FIRwkuqQJegqJQVm6Gb0bdz9mMA3xeN8QrqWrZgB18QIbJwLebZP9Dwh5iJVAT0-gDd2MG14ZBABStMw4sChUdKOeu9g6ronGmk2xYEF7t8isN8guRqbzyUDegfwXcgAYhHwMsV_Nr6l-EnUL-XdA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1648302561</pqid></control><display><type>article</type><title>Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome</title><source>MEDLINE</source><source>SAGE Journals</source><creator>Khogeer, H ; Alfattani, A ; Al Kaff, M ; Al shehri, T ; Khojah, O ; Owaidah, T</creator><creatorcontrib>Khogeer, H ; Alfattani, A ; Al Kaff, M ; Al shehri, T ; Khojah, O ; Owaidah, T</creatorcontrib><description>Background
Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (LA), anti-beta2 glycoprotein I (aβ2GPI) and anticardiolipin (aCL). The clinical significance of other antibodies like anti-phosphatidylserine antibodies (aPS) is still under investigation.
Objectives
The aim of the study was to assess the diagnostic value of aPS antibodies, and to compare their utility to that of other aPL antibodies.
Methods
We conducted a prospective observational study consisting of 212 patients with suspected thrombosis, pregnancy failure, or unexplained, prolonged clotting time. Data on demography, clinical presentation and autoantibody levels were assessed. Descriptive analysis, accuracy analysis, sensitivity, specificity, predictive value and likelihood ratio were calculated for aPS in comparison to other aPL.
Results
The diagnostic value of aPS versus other aPL antibodies revealed the high specificity of aPS (87%), with 70% of aPS-positive patients being confirmed APS. When the aPS test was used as a single test, it was effective for detection of confirmed APS cases (p < 0.01). Among 28 confirmed primary APS cases, 75% of patients were positive for aPS (p < 0.003). Moreover, by using aPS we detected three additional confirmed APS cases and another three probable cases.
Conclusion
Our findings reveal a significant association between aPS and APS, especially when used to diagnosis clinical cases with other negative aPL tests. There is an independent association between aPS and primary APS. In addition, these results demonstrated the advantages of using aPS as a diagnostic test for APS.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203314552462</identifier><identifier>PMID: 25253571</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies ; Antibodies, Antiphospholipid - immunology ; Anticoagulants ; Antiphospholipid Syndrome - diagnosis ; Antiphospholipid Syndrome - immunology ; Autoantibodies - immunology ; Child ; Child, Preschool ; Female ; Glycoproteins ; Hospitals ; Humans ; Laboratories ; Lupus ; Male ; Medicine ; Middle Aged ; Pathology ; Phosphatidylserines - immunology ; Pregnancy ; Prospective Studies ; Research centers ; Sensitivity and Specificity ; Thrombosis ; Thrombosis - etiology ; Thrombosis - immunology ; Young Adult</subject><ispartof>Lupus, 2015-02, Vol.24 (2), p.186-190</ispartof><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.</rights><rights>SAGE Publications © Feb 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-54734e39728e436ee6fbd822310381a829c96e35619c419ac114b2cedbec2aaf3</citedby><cites>FETCH-LOGICAL-c398t-54734e39728e436ee6fbd822310381a829c96e35619c419ac114b2cedbec2aaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203314552462$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203314552462$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25253571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khogeer, H</creatorcontrib><creatorcontrib>Alfattani, A</creatorcontrib><creatorcontrib>Al Kaff, M</creatorcontrib><creatorcontrib>Al shehri, T</creatorcontrib><creatorcontrib>Khojah, O</creatorcontrib><creatorcontrib>Owaidah, T</creatorcontrib><title>Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Background
Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (LA), anti-beta2 glycoprotein I (aβ2GPI) and anticardiolipin (aCL). The clinical significance of other antibodies like anti-phosphatidylserine antibodies (aPS) is still under investigation.
Objectives
The aim of the study was to assess the diagnostic value of aPS antibodies, and to compare their utility to that of other aPL antibodies.
Methods
We conducted a prospective observational study consisting of 212 patients with suspected thrombosis, pregnancy failure, or unexplained, prolonged clotting time. Data on demography, clinical presentation and autoantibody levels were assessed. Descriptive analysis, accuracy analysis, sensitivity, specificity, predictive value and likelihood ratio were calculated for aPS in comparison to other aPL.
Results
The diagnostic value of aPS versus other aPL antibodies revealed the high specificity of aPS (87%), with 70% of aPS-positive patients being confirmed APS. When the aPS test was used as a single test, it was effective for detection of confirmed APS cases (p < 0.01). Among 28 confirmed primary APS cases, 75% of patients were positive for aPS (p < 0.003). Moreover, by using aPS we detected three additional confirmed APS cases and another three probable cases.
Conclusion
Our findings reveal a significant association between aPS and APS, especially when used to diagnosis clinical cases with other negative aPL tests. There is an independent association between aPS and primary APS. In addition, these results demonstrated the advantages of using aPS as a diagnostic test for APS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Antibodies, Antiphospholipid - immunology</subject><subject>Anticoagulants</subject><subject>Antiphospholipid Syndrome - diagnosis</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Autoantibodies - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Glycoproteins</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lupus</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Phosphatidylserines - immunology</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Research centers</subject><subject>Sensitivity and Specificity</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - immunology</subject><subject>Young Adult</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1LxDAQxYMo7rp69yQFL16q-WraHpfFL1jwongsaTLdzdI2NWkP-9-btavIguBpYOb33mTyELok-JaQNL3DuSAUM0Z4klAu6BGaEp6mcejTYzTdjePdfILOvN9gjBnJxSma0IQmLEnJFL3P2950a-u7teyN3tYenGkhkqFdWm3AR9JH2shVa31vVGRabZTsrfORrb6wUW1r0xkd-W2rnW3gHJ1UMphd7OsMvT3cvy6e4uXL4_NivowVy7M-TnjKOLA8pRlwJgBEVeqMUkYwy4jMaK5yASwRJFec5FIRwkuqQJegqJQVm6Gb0bdz9mMA3xeN8QrqWrZgB18QIbJwLebZP9Dwh5iJVAT0-gDd2MG14ZBABStMw4sChUdKOeu9g6ronGmk2xYEF7t8isN8guRqbzyUDegfwXcgAYhHwMsV_Nr6l-EnUL-XdA</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Khogeer, H</creator><creator>Alfattani, A</creator><creator>Al Kaff, M</creator><creator>Al shehri, T</creator><creator>Khojah, O</creator><creator>Owaidah, T</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome</title><author>Khogeer, H ; Alfattani, A ; Al Kaff, M ; Al shehri, T ; Khojah, O ; Owaidah, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-54734e39728e436ee6fbd822310381a829c96e35619c419ac114b2cedbec2aaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Antibodies, Antiphospholipid - immunology</topic><topic>Anticoagulants</topic><topic>Antiphospholipid Syndrome - diagnosis</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Autoantibodies - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Glycoproteins</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Lupus</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Phosphatidylserines - immunology</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Research centers</topic><topic>Sensitivity and Specificity</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khogeer, H</creatorcontrib><creatorcontrib>Alfattani, A</creatorcontrib><creatorcontrib>Al Kaff, M</creatorcontrib><creatorcontrib>Al shehri, T</creatorcontrib><creatorcontrib>Khojah, O</creatorcontrib><creatorcontrib>Owaidah, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khogeer, H</au><au>Alfattani, A</au><au>Al Kaff, M</au><au>Al shehri, T</au><au>Khojah, O</au><au>Owaidah, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>24</volume><issue>2</issue><spage>186</spage><epage>190</epage><pages>186-190</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Background
Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (LA), anti-beta2 glycoprotein I (aβ2GPI) and anticardiolipin (aCL). The clinical significance of other antibodies like anti-phosphatidylserine antibodies (aPS) is still under investigation.
Objectives
The aim of the study was to assess the diagnostic value of aPS antibodies, and to compare their utility to that of other aPL antibodies.
Methods
We conducted a prospective observational study consisting of 212 patients with suspected thrombosis, pregnancy failure, or unexplained, prolonged clotting time. Data on demography, clinical presentation and autoantibody levels were assessed. Descriptive analysis, accuracy analysis, sensitivity, specificity, predictive value and likelihood ratio were calculated for aPS in comparison to other aPL.
Results
The diagnostic value of aPS versus other aPL antibodies revealed the high specificity of aPS (87%), with 70% of aPS-positive patients being confirmed APS. When the aPS test was used as a single test, it was effective for detection of confirmed APS cases (p < 0.01). Among 28 confirmed primary APS cases, 75% of patients were positive for aPS (p < 0.003). Moreover, by using aPS we detected three additional confirmed APS cases and another three probable cases.
Conclusion
Our findings reveal a significant association between aPS and APS, especially when used to diagnosis clinical cases with other negative aPL tests. There is an independent association between aPS and primary APS. In addition, these results demonstrated the advantages of using aPS as a diagnostic test for APS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25253571</pmid><doi>10.1177/0961203314552462</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibodies Antibodies, Antiphospholipid - immunology Anticoagulants Antiphospholipid Syndrome - diagnosis Antiphospholipid Syndrome - immunology Autoantibodies - immunology Child Child, Preschool Female Glycoproteins Hospitals Humans Laboratories Lupus Male Medicine Middle Aged Pathology Phosphatidylserines - immunology Pregnancy Prospective Studies Research centers Sensitivity and Specificity Thrombosis Thrombosis - etiology Thrombosis - immunology Young Adult |
| title | Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome |
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