EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells

The most widespread neoplasm of the pleura is malignant pleural mesothelioma (MPM) with low prevalence rate. The mechanistic target of rapamycin signaling pathway, inhibited by RAD001, was shown to be deregulated in MPM development and considered a novel target for the MPM therapy. The EF24, a curcu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human & experimental toxicology 2015-02, Vol.34 (2), p.117-126
Hauptverfasser:	Onen, HI, Yilmaz, A, Alp, E, Celik, A, Demiroz, SM, Konac, E, Kurul, IC, Menevse, ES
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Caspase 3 - metabolism Caspase 9 - genetics Cell Line Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cells Chemotherapy Cisplatin - pharmacology Curcumin - analogs & derivatives Curcumin - pharmacology DNA Fragmentation Everolimus Humans Lung cancer Mesothelioma Organoplatinum Compounds - pharmacology Pharmacology Pleural Neoplasms Proto-Oncogene Proteins c-bcl-2 - genetics Sirolimus - analogs & derivatives Sirolimus - pharmacology Toxicology
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!