Bradycardia Related to Ribavirin in Four Pediatric Patients with Crimean-Congo Hemorrhagic Fever
Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal fever due to infection with the CCHF virus, which belongs to the genus Nairovirus in the Bunyaviridae family and causes severe disease in humans, with reported mortality rates of 15–70% (Centers for Disease Control and Prevention 1983 )....
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| Veröffentlicht in: | Vector borne and zoonotic diseases (Larchmont, N.Y.) N.Y.), 2014-06, Vol.14 (6), p.464-465 |
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| container_title | Vector borne and zoonotic diseases (Larchmont, N.Y.) |
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| creator | Tezer, Hasan Özkaya Parlakay, Aslınur Gülhan, Belgin Cetin, Ilker |
| description | Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal fever due to infection with the CCHF virus, which belongs to the genus
Nairovirus
in the Bunyaviridae family and causes severe disease in humans, with reported mortality rates of 15–70% (Centers for Disease Control and Prevention
1983
). Humans become infected through the bites of ticks, by contact with blood or tissue from viremic livestock, or by contact with a patient with CCHF during the acute phase of infection (Khan et al.
1997
). Uysal et al. (
2012
) reported bradycardia in a patient with CCHF related to ribavirin treatment. We have observed the same side effect in four pediatric patients that also resolved with discontinuation of ribavirin. |
| doi_str_mv | 10.1089/vbz.2012.1294 |
| format | Article |
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Nairovirus
in the Bunyaviridae family and causes severe disease in humans, with reported mortality rates of 15–70% (Centers for Disease Control and Prevention
1983
). Humans become infected through the bites of ticks, by contact with blood or tissue from viremic livestock, or by contact with a patient with CCHF during the acute phase of infection (Khan et al.
1997
). Uysal et al. (
2012
) reported bradycardia in a patient with CCHF related to ribavirin treatment. We have observed the same side effect in four pediatric patients that also resolved with discontinuation of ribavirin.</description><identifier>ISSN: 1530-3667</identifier><identifier>EISSN: 1557-7759</identifier><identifier>DOI: 10.1089/vbz.2012.1294</identifier><identifier>PMID: 24745325</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Animals ; Antiviral Agents - adverse effects ; Antiviral Agents - therapeutic use ; Arachnid Vectors - virology ; Bradycardia - chemically induced ; Bradycardia - diagnosis ; Bunyaviridae ; Child ; Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification ; Hemorrhagic Fever, Crimean - drug therapy ; Hemorrhagic Fever, Crimean - virology ; Humans ; Ixodidae ; Nairovirus ; Ribavirin - adverse effects ; Ribavirin - therapeutic use ; Short Communications ; Tick Bites - complications ; Ticks - virology ; Viremia</subject><ispartof>Vector borne and zoonotic diseases (Larchmont, N.Y.), 2014-06, Vol.14 (6), p.464-465</ispartof><rights>2014, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-380523214034fca2af365fa368e19bad8fffb697f7ea012c97ead92e7a6b239d3</citedby><cites>FETCH-LOGICAL-c370t-380523214034fca2af365fa368e19bad8fffb697f7ea012c97ead92e7a6b239d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24745325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tezer, Hasan</creatorcontrib><creatorcontrib>Özkaya Parlakay, Aslınur</creatorcontrib><creatorcontrib>Gülhan, Belgin</creatorcontrib><creatorcontrib>Cetin, Ilker</creatorcontrib><title>Bradycardia Related to Ribavirin in Four Pediatric Patients with Crimean-Congo Hemorrhagic Fever</title><title>Vector borne and zoonotic diseases (Larchmont, N.Y.)</title><addtitle>Vector Borne Zoonotic Dis</addtitle><description>Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal fever due to infection with the CCHF virus, which belongs to the genus
Nairovirus
in the Bunyaviridae family and causes severe disease in humans, with reported mortality rates of 15–70% (Centers for Disease Control and Prevention
1983
). Humans become infected through the bites of ticks, by contact with blood or tissue from viremic livestock, or by contact with a patient with CCHF during the acute phase of infection (Khan et al.
1997
). Uysal et al. (
2012
) reported bradycardia in a patient with CCHF related to ribavirin treatment. We have observed the same side effect in four pediatric patients that also resolved with discontinuation of ribavirin.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Antiviral Agents - adverse effects</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Arachnid Vectors - virology</subject><subject>Bradycardia - chemically induced</subject><subject>Bradycardia - diagnosis</subject><subject>Bunyaviridae</subject><subject>Child</subject><subject>Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification</subject><subject>Hemorrhagic Fever, Crimean - drug therapy</subject><subject>Hemorrhagic Fever, Crimean - virology</subject><subject>Humans</subject><subject>Ixodidae</subject><subject>Nairovirus</subject><subject>Ribavirin - adverse effects</subject><subject>Ribavirin - therapeutic use</subject><subject>Short Communications</subject><subject>Tick Bites - complications</subject><subject>Ticks - virology</subject><subject>Viremia</subject><issn>1530-3667</issn><issn>1557-7759</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVJiV0nx16Djrmsq4-VtDq2Jm4CgQbTnjezu6NEYb3rSrJL-uurxW6ugYF3GB5emIeQz5wtOavsl0PzdykYF0subPmBzLlSpjBG2bNpl6yQWpsZ-RTjC2OCV1ydk5koTamkUHPy-C1A99pC6DzQDfaQsKNppBvfwMEHP9A863Ef6ANmJAXf0gdIHocU6R-fnukq-C3CUKzG4Wmkt7gdQ3iGp8yt8YDhgnx00Ee8POWC_Frf_FzdFvc_vt-tvt4XrTQsFbJiSkjBSyZL14IAJ7VyIHWF3DbQVc65RlvjDEL-trU5OyvQgG6EtJ1ckOtj7y6Mv_cYU731scW-hwHHfay51pVQTGn9Pqqk0tmOtBktjmgbxhgDunqX34XwWnNWT_7r7L-e_NeT_8xfnar3zRa7N_q_8AzIIzCdYRh6jw2G9E7tP8z7ki8</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Tezer, Hasan</creator><creator>Özkaya Parlakay, Aslınur</creator><creator>Gülhan, Belgin</creator><creator>Cetin, Ilker</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140601</creationdate><title>Bradycardia Related to Ribavirin in Four Pediatric Patients with Crimean-Congo Hemorrhagic Fever</title><author>Tezer, Hasan ; Özkaya Parlakay, Aslınur ; Gülhan, Belgin ; Cetin, Ilker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-380523214034fca2af365fa368e19bad8fffb697f7ea012c97ead92e7a6b239d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Antiviral Agents - adverse effects</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Arachnid Vectors - virology</topic><topic>Bradycardia - chemically induced</topic><topic>Bradycardia - diagnosis</topic><topic>Bunyaviridae</topic><topic>Child</topic><topic>Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification</topic><topic>Hemorrhagic Fever, Crimean - drug therapy</topic><topic>Hemorrhagic Fever, Crimean - virology</topic><topic>Humans</topic><topic>Ixodidae</topic><topic>Nairovirus</topic><topic>Ribavirin - adverse effects</topic><topic>Ribavirin - therapeutic use</topic><topic>Short Communications</topic><topic>Tick Bites - complications</topic><topic>Ticks - virology</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tezer, Hasan</creatorcontrib><creatorcontrib>Özkaya Parlakay, Aslınur</creatorcontrib><creatorcontrib>Gülhan, Belgin</creatorcontrib><creatorcontrib>Cetin, Ilker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tezer, Hasan</au><au>Özkaya Parlakay, Aslınur</au><au>Gülhan, Belgin</au><au>Cetin, Ilker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradycardia Related to Ribavirin in Four Pediatric Patients with Crimean-Congo Hemorrhagic Fever</atitle><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle><addtitle>Vector Borne Zoonotic Dis</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>14</volume><issue>6</issue><spage>464</spage><epage>465</epage><pages>464-465</pages><issn>1530-3667</issn><eissn>1557-7759</eissn><abstract>Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal fever due to infection with the CCHF virus, which belongs to the genus
Nairovirus
in the Bunyaviridae family and causes severe disease in humans, with reported mortality rates of 15–70% (Centers for Disease Control and Prevention
1983
). Humans become infected through the bites of ticks, by contact with blood or tissue from viremic livestock, or by contact with a patient with CCHF during the acute phase of infection (Khan et al.
1997
). Uysal et al. (
2012
) reported bradycardia in a patient with CCHF related to ribavirin treatment. We have observed the same side effect in four pediatric patients that also resolved with discontinuation of ribavirin.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>24745325</pmid><doi>10.1089/vbz.2012.1294</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-3667 |
| ispartof | Vector borne and zoonotic diseases (Larchmont, N.Y.), 2014-06, Vol.14 (6), p.464-465 |
| issn | 1530-3667 1557-7759 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Animals Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Arachnid Vectors - virology Bradycardia - chemically induced Bradycardia - diagnosis Bunyaviridae Child Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification Hemorrhagic Fever, Crimean - drug therapy Hemorrhagic Fever, Crimean - virology Humans Ixodidae Nairovirus Ribavirin - adverse effects Ribavirin - therapeutic use Short Communications Tick Bites - complications Ticks - virology Viremia |
| title | Bradycardia Related to Ribavirin in Four Pediatric Patients with Crimean-Congo Hemorrhagic Fever |
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