Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)

Abstract Objectives Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demo...

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Veröffentlicht in:	Transplant immunology 2015-03, Vol.32 (2), p.72-75
Hauptverfasser:	Gong, Weihua, Shou, Dawei, Cheng, Fei, Shi, Jianguang, Ge, Fangmin, Liu, Dahai
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Graft Survival - genetics Graft Survival - immunology Heart Transplantation Interleukin-6 Interleukin-6 - deficiency Interleukin-6 - immunology Male Mice Mice, Inbred BALB C Mice, Knockout Myeloid Cells - immunology Myeloid-derived suppressor cells Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology Tolerance Transplantation Tolerance - genetics
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