Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)
Abstract Objectives Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demo...
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| Veröffentlicht in: | Transplant immunology 2015-03, Vol.32 (2), p.72-75 |
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| creator | Gong, Weihua Shou, Dawei Cheng, Fei Shi, Jianguang Ge, Fangmin Liu, Dahai |
| description | Abstract Objectives Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demonstrate the role of MDSCs by transplanting IL-6 deficient heart grafts into wild-type recipients in a murine allogeneic transplant model. Results Our data further revealed that utilization of IL-6 deficient heart grafts could cause a significant prolongation of allograft survival (Mantel–Cox Test, p = 0.001; Gehan–Breslow–Wilcoxon Test, p = 0.0016) and a remarkable increase of the frequency of CD11b + Gr1 − low in the recipients' spleens (p = 0.0028). Conclusions MDSCs rather than Th17 cells are closely involved in induced tolerance by IL-6 deficient donor heart. This unveiled mechanism of targeting IL-6 or its signaling pathway may provide a novel insight into preventing allograft rejection for non-sensitized transplant recipients. |
| doi_str_mv | 10.1016/j.trim.2015.02.001 |
| format | Article |
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However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demonstrate the role of MDSCs by transplanting IL-6 deficient heart grafts into wild-type recipients in a murine allogeneic transplant model. Results Our data further revealed that utilization of IL-6 deficient heart grafts could cause a significant prolongation of allograft survival (Mantel–Cox Test, p = 0.001; Gehan–Breslow–Wilcoxon Test, p = 0.0016) and a remarkable increase of the frequency of CD11b + Gr1 − low in the recipients' spleens (p = 0.0028). Conclusions MDSCs rather than Th17 cells are closely involved in induced tolerance by IL-6 deficient donor heart. This unveiled mechanism of targeting IL-6 or its signaling pathway may provide a novel insight into preventing allograft rejection for non-sensitized transplant recipients.</description><identifier>ISSN: 0966-3274</identifier><identifier>EISSN: 1878-5492</identifier><identifier>DOI: 10.1016/j.trim.2015.02.001</identifier><identifier>PMID: 25680847</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Graft Survival - genetics ; Graft Survival - immunology ; Heart Transplantation ; Interleukin-6 ; Interleukin-6 - deficiency ; Interleukin-6 - immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Myeloid Cells - immunology ; Myeloid-derived suppressor cells ; Signal Transduction - genetics ; Signal Transduction - immunology ; T-Lymphocytes, Regulatory - immunology ; Th17 Cells - immunology ; Tolerance ; Transplantation Tolerance - genetics</subject><ispartof>Transplant immunology, 2015-03, Vol.32 (2), p.72-75</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-acc74960976b2102ccc3b2082860c8c7dc16cbfb60a02f0af3e75aeeb186eaac3</citedby><cites>FETCH-LOGICAL-c514t-acc74960976b2102ccc3b2082860c8c7dc16cbfb60a02f0af3e75aeeb186eaac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0966327415000052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25680847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Weihua</creatorcontrib><creatorcontrib>Shou, Dawei</creatorcontrib><creatorcontrib>Cheng, Fei</creatorcontrib><creatorcontrib>Shi, Jianguang</creatorcontrib><creatorcontrib>Ge, Fangmin</creatorcontrib><creatorcontrib>Liu, Dahai</creatorcontrib><title>Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)</title><title>Transplant immunology</title><addtitle>Transpl Immunol</addtitle><description>Abstract Objectives Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demonstrate the role of MDSCs by transplanting IL-6 deficient heart grafts into wild-type recipients in a murine allogeneic transplant model. Results Our data further revealed that utilization of IL-6 deficient heart grafts could cause a significant prolongation of allograft survival (Mantel–Cox Test, p = 0.001; Gehan–Breslow–Wilcoxon Test, p = 0.0016) and a remarkable increase of the frequency of CD11b + Gr1 − low in the recipients' spleens (p = 0.0028). Conclusions MDSCs rather than Th17 cells are closely involved in induced tolerance by IL-6 deficient donor heart. This unveiled mechanism of targeting IL-6 or its signaling pathway may provide a novel insight into preventing allograft rejection for non-sensitized transplant recipients.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Graft Survival - genetics</subject><subject>Graft Survival - immunology</subject><subject>Heart Transplantation</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - deficiency</subject><subject>Interleukin-6 - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>Myeloid Cells - immunology</subject><subject>Myeloid-derived suppressor cells</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Tolerance</subject><subject>Transplantation Tolerance - genetics</subject><issn>0966-3274</issn><issn>1878-5492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGL1DAYhoMo7uzqH_AgOa6H1i9pk6YggoyrLox42PUc0vSrZuwkY9IO9N-bMqsHD-IpkLzPR3ifj5AXDEoGTL7el1N0h5IDEyXwEoA9IhumGlWIuuWPyQZaKYuKN_UFuUxpDwBctM1TcsGFVKDqZkPm-zBiNN4idb6fLfa0W-jtrpC0x8FZh36iffAh0u9o4kRdosl98y6_GT-NS8ZOYTxlznl6WHAMri96jG69SvPxGDGlTFscx0SvP7-_26ZXz8iTwYwJnz-cV-Trh5v77adi9-Xj7fbdrrCC1VNhrG3qVkLbyI4z4NbaquOguJJglW16y6Tthk6CAT6AGSpshEHsmJJojK2uyPV57jGGnzOmSR9cWn9iPIY5aSal4gLqqvqfqGCsUTXPUX6O2hhSijjoY_Zg4qIZ6NWM3uvVjF7NaOA6m8nQy4f5c3fA_g_yW0UOvDkHMBdychh1WtvPRlxEO-k-uH_Pf_sXbkfns6TxBy6Y9mGOPletmU4Z0HfrbqyrwUReCxC8-gVzbbUl</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Gong, Weihua</creator><creator>Shou, Dawei</creator><creator>Cheng, Fei</creator><creator>Shi, Jianguang</creator><creator>Ge, Fangmin</creator><creator>Liu, Dahai</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150301</creationdate><title>Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)</title><author>Gong, Weihua ; Shou, Dawei ; Cheng, Fei ; Shi, Jianguang ; Ge, Fangmin ; Liu, Dahai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-acc74960976b2102ccc3b2082860c8c7dc16cbfb60a02f0af3e75aeeb186eaac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Graft Survival - genetics</topic><topic>Graft Survival - immunology</topic><topic>Heart Transplantation</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - deficiency</topic><topic>Interleukin-6 - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Knockout</topic><topic>Myeloid Cells - immunology</topic><topic>Myeloid-derived suppressor cells</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th17 Cells - immunology</topic><topic>Tolerance</topic><topic>Transplantation Tolerance - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Weihua</creatorcontrib><creatorcontrib>Shou, Dawei</creatorcontrib><creatorcontrib>Cheng, Fei</creatorcontrib><creatorcontrib>Shi, Jianguang</creatorcontrib><creatorcontrib>Ge, Fangmin</creatorcontrib><creatorcontrib>Liu, Dahai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplant immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Weihua</au><au>Shou, Dawei</au><au>Cheng, Fei</au><au>Shi, Jianguang</au><au>Ge, Fangmin</au><au>Liu, Dahai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)</atitle><jtitle>Transplant immunology</jtitle><addtitle>Transpl Immunol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>32</volume><issue>2</issue><spage>72</spage><epage>75</epage><pages>72-75</pages><issn>0966-3274</issn><eissn>1878-5492</eissn><abstract>Abstract Objectives Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process. Materials and methods In this study, we demonstrate the role of MDSCs by transplanting IL-6 deficient heart grafts into wild-type recipients in a murine allogeneic transplant model. Results Our data further revealed that utilization of IL-6 deficient heart grafts could cause a significant prolongation of allograft survival (Mantel–Cox Test, p = 0.001; Gehan–Breslow–Wilcoxon Test, p = 0.0016) and a remarkable increase of the frequency of CD11b + Gr1 − low in the recipients' spleens (p = 0.0028). Conclusions MDSCs rather than Th17 cells are closely involved in induced tolerance by IL-6 deficient donor heart. This unveiled mechanism of targeting IL-6 or its signaling pathway may provide a novel insight into preventing allograft rejection for non-sensitized transplant recipients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25680847</pmid><doi>10.1016/j.trim.2015.02.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Graft Survival - genetics Graft Survival - immunology Heart Transplantation Interleukin-6 Interleukin-6 - deficiency Interleukin-6 - immunology Male Mice Mice, Inbred BALB C Mice, Knockout Myeloid Cells - immunology Myeloid-derived suppressor cells Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology Tolerance Transplantation Tolerance - genetics |
| title | Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs) |
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