Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats

Rationale Evidence is emerging that positive and negative modulation of the metabotropic glutamate (mGluR5) receptors has the potential for treating cognitive deficits and neuroprotection associated with psychiatric and neurodegenerative diseases, respectively. Sleep and synchronisation of disparate...

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Veröffentlicht in:	Psychopharmacology 2015-03, Vol.232 (6), p.1107-1122
Hauptverfasser:	Ahnaou, A., Langlois, X., Steckler, T., Bartolome-Nebreda, J. M., Drinkenburg, W. H. I. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Animals Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Circadian Rhythm - drug effects Circadian Rhythm - physiology Cognition Cognition - drug effects Cognition - physiology Cognitive ability Electroencephalography Excitatory Amino Acid Antagonists - pharmacology Glutamate Male Nerve Net - drug effects Nerve Net - physiology Neurobiology Neuroplasticity Neuroprotective Agents - pharmacology Neurosciences Original Investigation Pharmacology/Toxicology Physiological aspects Psychiatry Psychopharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors Receptor, Metabotropic Glutamate 5 - metabolism Rodents Sleep Sleep - drug effects Sleep - physiology Thiazoles - pharmacology
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