Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption

In humans, plasma haptoglobin (Hp) and the macrophage receptor CD163 promote a fast scavenging of hemoglobin (Hb). In the present study, we have compared the mouse and human CD163-mediated binding and uptake of Hb and HpHb complex in vitro and characterized the CD163-mediated plasma clearance of Hb...

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Veröffentlicht in:	Antioxidants & redox signaling 2013-06, Vol.18 (17), p.2254-2263
Hauptverfasser:	Etzerodt, Anders, Kjolby, Mads, Nielsen, Marianne Jensby, Maniecki, Maciej, Svendsen, Pia, Moestrup, Søren Kragh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism CHO Cells Cricetinae Cricetulus Gene Expression Gene Targeting Genotype Haptoglobins - metabolism Hemoglobins - metabolism Humans Mice Mice, Knockout Multiprotein Complexes - metabolism Protein Binding Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Surface Plasmon Resonance
Online-Zugang:	Volltext
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