Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines
Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of nar...
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| Veröffentlicht in: | Inflammation 2015-04, Vol.38 (2), p.846-857 |
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| creator | Ahmad, Sheikh Fayaz Attia, Sabry M. Bakheet, Saleh A. Zoheir, Khairy M. A. Ansari, Mushtaq Ahmad Korashy, Hesham M. Abdel-Hamied, Hala E. Ashour, Abdelkader E. Abd-Allah, Adel R. A. |
| description | Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions. |
| doi_str_mv | 10.1007/s10753-014-9994-y |
| format | Article |
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A. ; Ansari, Mushtaq Ahmad ; Korashy, Hesham M. ; Abdel-Hamied, Hala E. ; Ashour, Abdelkader E. ; Abd-Allah, Adel R. A.</creator><creatorcontrib>Ahmad, Sheikh Fayaz ; Attia, Sabry M. ; Bakheet, Saleh A. ; Zoheir, Khairy M. A. ; Ansari, Mushtaq Ahmad ; Korashy, Hesham M. ; Abdel-Hamied, Hala E. ; Ashour, Abdelkader E. ; Abd-Allah, Adel R. A.</creatorcontrib><description>Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-014-9994-y</identifier><identifier>PMID: 25117567</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Carrageenan - toxicity ; Cytokines - antagonists & inhibitors ; Cytokines - metabolism ; Dose-Response Relationship, Drug ; Female ; Flavanones - pharmacology ; Flavanones - therapeutic use ; I-kappa B Kinase - antagonists & inhibitors ; I-kappa B Kinase - metabolism ; Immunology ; Inflammation Mediators - antagonists & inhibitors ; Inflammation Mediators - metabolism ; Internal Medicine ; Mice ; Mice, Inbred BALB C ; NF-kappa B - antagonists & inhibitors ; NF-kappa B - metabolism ; Pathology ; Pharmacology/Toxicology ; Pleurisy - metabolism ; Pleurisy - prevention & control ; Rheumatology ; STAT3 Transcription Factor - antagonists & inhibitors ; STAT3 Transcription Factor - metabolism]]></subject><ispartof>Inflammation, 2015-04, Vol.38 (2), p.846-857</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-8c3d627ca4c0cf9056bc82a41f0559b402a82bfe9f60ec05d97a80958838c6b63</citedby><cites>FETCH-LOGICAL-c420t-8c3d627ca4c0cf9056bc82a41f0559b402a82bfe9f60ec05d97a80958838c6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-014-9994-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-014-9994-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25117567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, Sheikh Fayaz</creatorcontrib><creatorcontrib>Attia, Sabry M.</creatorcontrib><creatorcontrib>Bakheet, Saleh A.</creatorcontrib><creatorcontrib>Zoheir, Khairy M. A.</creatorcontrib><creatorcontrib>Ansari, Mushtaq Ahmad</creatorcontrib><creatorcontrib>Korashy, Hesham M.</creatorcontrib><creatorcontrib>Abdel-Hamied, Hala E.</creatorcontrib><creatorcontrib>Ashour, Abdelkader E.</creatorcontrib><creatorcontrib>Abd-Allah, Adel R. A.</creatorcontrib><title>Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carrageenan - toxicity</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Flavanones - pharmacology</subject><subject>Flavanones - therapeutic use</subject><subject>I-kappa B Kinase - antagonists & inhibitors</subject><subject>I-kappa B Kinase - metabolism</subject><subject>Immunology</subject><subject>Inflammation Mediators - antagonists & inhibitors</subject><subject>Inflammation Mediators - metabolism</subject><subject>Internal Medicine</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>NF-kappa B - antagonists & inhibitors</subject><subject>NF-kappa B - metabolism</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Pleurisy - metabolism</subject><subject>Pleurisy - prevention & control</subject><subject>Rheumatology</subject><subject>STAT3 Transcription Factor - antagonists & inhibitors</subject><subject>STAT3 Transcription Factor - metabolism</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS0EokPhA9ggL1lgsJPYsZdhaGGkoUViWEeO8zJJSezBdpDyWWz7EcMvkZlpK3XDytZ7517ZOgi9ZvQ9ozT_EBjNeUooy4hSKiPTE7RgPE9JwnPxFC1oKihJlcrP0IsQbiilUsn0OTpLOGM5F_kC_b3SvrPbzuIiRrCjjhBwbAF_gt_Qu90ANmLX4KX2Xm8BrLZkZevRQI0LM0bA69Fu8co2vR4GHTtn8ab1bty287Dtqu44mhuuLsn-tnqHv2-KTYq1rfE378hD0PkJf4W6O9zCcX1hW20N3L9gtb_9uP9z3BQ2do-Tyym6n52F8BI9a3Qf4NXdeY5-XF5sll_I-vrzalmsickSGok0aS2S3OjMUNMoykVlZKIz1lDOVZXRRMukakA1goKhvFa5llRxKVNpRCXSc_T21Lvz7tcIIZZDFwz0vbbgxlAyIWSSzXw2o-yEGu9C8NCUO98N2k8lo-XBY3nyWM4ey4PHcpozb-7qx2qA-iFxL24GkhMQdgd_4MsbN3o7f_k_rf8AU7eujQ</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Ahmad, Sheikh Fayaz</creator><creator>Attia, Sabry M.</creator><creator>Bakheet, Saleh A.</creator><creator>Zoheir, Khairy M. 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A.</creatorcontrib><creatorcontrib>Ansari, Mushtaq Ahmad</creatorcontrib><creatorcontrib>Korashy, Hesham M.</creatorcontrib><creatorcontrib>Abdel-Hamied, Hala E.</creatorcontrib><creatorcontrib>Ashour, Abdelkader E.</creatorcontrib><creatorcontrib>Abd-Allah, Adel R. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmad, Sheikh Fayaz</au><au>Attia, Sabry M.</au><au>Bakheet, Saleh A.</au><au>Zoheir, Khairy M. A.</au><au>Ansari, Mushtaq Ahmad</au><au>Korashy, Hesham M.</au><au>Abdel-Hamied, Hala E.</au><au>Ashour, Abdelkader E.</au><au>Abd-Allah, Adel R. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>38</volume><issue>2</issue><spage>846</spage><epage>857</epage><pages>846-857</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25117567</pmid><doi>10.1007/s10753-014-9994-y</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Carrageenan - toxicity Cytokines - antagonists & inhibitors Cytokines - metabolism Dose-Response Relationship, Drug Female Flavanones - pharmacology Flavanones - therapeutic use I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - metabolism Immunology Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Internal Medicine Mice Mice, Inbred BALB C NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Pathology Pharmacology/Toxicology Pleurisy - metabolism Pleurisy - prevention & control Rheumatology STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism |
| title | Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines |
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