ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1

ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be significantly associated genomewide with coronary artery disease. However, the mechanisms that link ADAMTS-7 and coronary artery disease risk remain elusive. We have...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2015-03, Vol.131 (13), p.1191-1201
Hauptverfasser:	Kessler, Thorsten, Zhang, Lu, Liu, Ziyi, Yin, Xiaoke, Huang, Yaqian, Wang, Yingbao, Fu, Yi, Mayr, Manuel, Ge, Qing, Xu, Qingbo, Zhu, Yi, Wang, Xian, Schmidt, Kjestine, de Wit, Cor, Erdmann, Jeanette, Schunkert, Heribert, Aherrahrou, Zouhair, Kong, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - deficiency ADAM Proteins - genetics ADAM Proteins - physiology ADAMTS7 Protein Amino Acid Sequence Animals Carotid Artery Injuries - enzymology Carotid Artery Injuries - pathology Carotid Artery, Common - enzymology Cell Division Cells, Cultured Endothelial Cells - metabolism Femoral Artery - injuries Femoral Artery - pathology Human Umbilical Vein Endothelial Cells Humans Male Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Myocytes, Smooth Muscle - metabolism Neointima - enzymology Neointima - pathology Protein Interaction Mapping Rats RNA Interference RNA, Small Interfering - pharmacology Thrombospondin 1 - deficiency Thrombospondin 1 - genetics Thrombospondin 1 - physiology Vascular Remodeling - physiology
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