The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor
•We investigate the effects of Ginkgo biloba on spatial and emotional behaviors.•Ginkgo biloba supplementation improves cognitive functions.•Ginkgo biloba decreased lipid peroxidation in brain.•Ginkgo biloba also elevated brain-derived neurotrophic factor levels in blood. The aim of this study was t...
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| Veröffentlicht in: | Behavioural brain research 2015-02, Vol.278, p.453-461 |
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| creator | Belviranlı, Muaz Okudan, Nilsel |
| description | •We investigate the effects of Ginkgo biloba on spatial and emotional behaviors.•Ginkgo biloba supplementation improves cognitive functions.•Ginkgo biloba decreased lipid peroxidation in brain.•Ginkgo biloba also elevated brain-derived neurotrophic factor levels in blood.
The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats. |
| doi_str_mv | 10.1016/j.bbr.2014.10.032 |
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The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2014.10.032</identifier><identifier>PMID: 25446810</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aging ; Aging - drug effects ; Animals ; BDNF ; Brain-Derived Neurotrophic Factor - metabolism ; Cognition - drug effects ; Cognitive function ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - blood ; Exploratory Behavior - drug effects ; Female ; Ginkgo biloba ; Ginkgo biloba - chemistry ; Glutathione - blood ; Malondialdehyde - blood ; Maze Learning - drug effects ; Memory ; Oxidative stress ; Oxidative Stress - physiology ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Statistics, Nonparametric ; Superoxide Dismutase - blood ; Time Factors</subject><ispartof>Behavioural brain research, 2015-02, Vol.278, p.453-461</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-ce513f506205d26e2b3e959cece6c6116c275f0b43231ee9ab49ebfb19d1ed243</citedby><cites>FETCH-LOGICAL-c386t-ce513f506205d26e2b3e959cece6c6116c275f0b43231ee9ab49ebfb19d1ed243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432814006974$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25446810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belviranlı, Muaz</creatorcontrib><creatorcontrib>Okudan, Nilsel</creatorcontrib><title>The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>•We investigate the effects of Ginkgo biloba on spatial and emotional behaviors.•Ginkgo biloba supplementation improves cognitive functions.•Ginkgo biloba decreased lipid peroxidation in brain.•Ginkgo biloba also elevated brain-derived neurotrophic factor levels in blood.
The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Animals</subject><subject>BDNF</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cognition - drug effects</subject><subject>Cognitive function</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - blood</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Ginkgo biloba</subject><subject>Ginkgo biloba - chemistry</subject><subject>Glutathione - blood</subject><subject>Malondialdehyde - blood</subject><subject>Maze Learning - drug effects</subject><subject>Memory</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Statistics, Nonparametric</subject><subject>Superoxide Dismutase - blood</subject><subject>Time Factors</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOHDEQRa0oKAwkH5BN5GU2Pdhut7ubrCIUHhISG7K2_CgPnvTYg-1G8B354XgYYImysqp06lq6B6GvlCwpoeJkvdQ6LRmhvM5L0rIPaEGHnjV9x8ePaFEZ0fCWDYfoKOc1IYSTjn5Ch6zjXAyULNDf2zvA4ByYknF0-MKHP6uItZ-iVhgeS1Km4Biwiavgi38A7OZgio8hYx-wWoHFDjZqApxUyad4F5hiHWtafPRWPR_lkiBnrILFOikfGgup7i0OMKdYUtzeeYNd_Symz-jAqSnDl5f3GP0-_3V7dtlc31xcnf28bkw7iNIY6GjrOiIY6SwTwHQLYzcaMCCMoFQY1neO6FpASwFGpfkI2mk6WgqW8fYYfd_nblO8nyEXufHZwDSpAHHOsrY3MF7z2X-gvCdk6AWtKN2jJsWcEzi5TX6j0pOkRO60ybWs2uRO225VtdWbby_xs96Afbt49VSBH3sAah8PHpLMxkMwYH2q6qSN_p34f6nvqhI</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Belviranlı, Muaz</creator><creator>Okudan, Nilsel</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor</title><author>Belviranlı, Muaz ; Okudan, Nilsel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ce513f506205d26e2b3e959cece6c6116c275f0b43231ee9ab49ebfb19d1ed243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Animals</topic><topic>BDNF</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cognition - drug effects</topic><topic>Cognitive function</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - blood</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Ginkgo biloba</topic><topic>Ginkgo biloba - chemistry</topic><topic>Glutathione - blood</topic><topic>Malondialdehyde - blood</topic><topic>Maze Learning - drug effects</topic><topic>Memory</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Statistics, Nonparametric</topic><topic>Superoxide Dismutase - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belviranlı, Muaz</creatorcontrib><creatorcontrib>Okudan, Nilsel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belviranlı, Muaz</au><au>Okudan, Nilsel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>278</volume><spage>453</spage><epage>461</epage><pages>453-461</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>•We investigate the effects of Ginkgo biloba on spatial and emotional behaviors.•Ginkgo biloba supplementation improves cognitive functions.•Ginkgo biloba decreased lipid peroxidation in brain.•Ginkgo biloba also elevated brain-derived neurotrophic factor levels in blood.
The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25446810</pmid><doi>10.1016/j.bbr.2014.10.032</doi><tpages>9</tpages></addata></record> |
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| subjects | Aging Aging - drug effects Animals BDNF Brain-Derived Neurotrophic Factor - metabolism Cognition - drug effects Cognitive function Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood Exploratory Behavior - drug effects Female Ginkgo biloba Ginkgo biloba - chemistry Glutathione - blood Malondialdehyde - blood Maze Learning - drug effects Memory Oxidative stress Oxidative Stress - physiology Plant Extracts - pharmacology Rats Rats, Wistar Statistics, Nonparametric Superoxide Dismutase - blood Time Factors |
| title | The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor |
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