Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions

Background: Microglia activation mediated by toll-like receptor 4 (TLR4) plays an important role in neuroinflammation and postoperative cognitive dysfunction (POCD). Diabetes mellitus (DM) has been recently suggested as an independent risk factor for POCD. In this study, we investigate the potential...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.35 (4), p.1571-1581
Hauptverfasser:	Zhang, Xiang, Dong, Hongquan, Zhang, Susu, Lu, Shunmei, Sun, Jie, Qian, Yanning
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Genetic aspects Glucose - pharmacology Glucose metabolism Health aspects High glucose Inflammation Interleukin-6 - metabolism JAK2/STAT3 Janus Kinase 2 - metabolism Lipopolysaccharides Lipopolysaccharides - toxicity Microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Original Paper Rats Rats, Sprague-Dawley Signal Transduction - drug effects STAT3 Transcription Factor - metabolism TLR4 Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!