Binding of prorenin to (pro)renin receptor induces the proliferation of human umbilical artery smooth muscle cells via ROS generation and ERK1/2 activation

Introduction: Since the discovery of the (pro)renin receptor (PRR), it has been considered as a novel bioactive molecule of the renin–angiotensin system (RAS). The activation of PRR can elicit a series of angiotensin II (AngII)-independent effects. Materials and methods: In this study, we investigat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the renin-angiotensin-aldosterone system 2014-06, Vol.15 (2), p.99-108
Hauptverfasser:	Liu, Feng Y, Liu, Xiao Y, Zhang, Li J, Cheng, Yun P, Jiang, Yi N
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein - biosynthesis Cell Proliferation - drug effects Female Human Umbilical Vein Endothelial Cells - drug effects Humans MAP Kinase Signaling System - drug effects NADPH Oxidases - antagonists & inhibitors Phosphorylation Pregnancy Proto-Oncogene Proteins c-bcl-2 - biosynthesis Reactive Oxygen Species - metabolism Receptors, Cell Surface - metabolism Renin - metabolism Vacuolar Proton-Translocating ATPases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!