LMP-1 induces survivin expression to inhibit cell apoptosis through the NF-κB and PI3K/Akt signaling pathways in nasal NK/T-cell lymphoma

The latent membrane protein-1 (LMP-1) is essential for Epstein-Barr virus (EBV)-induced nasal natural killer/T-cell lymphoma (NKTL). The aim of the present study was to evaluate the role of LMP-1 in NKTL. Two human EBV-positive NKTL cell lines (SNK-6 and SNT-8) were transfected with pcDNA3.1-LMP-1 o...

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Veröffentlicht in:	Oncology reports 2015-05, Vol.33 (5), p.2253-2260
Hauptverfasser:	SUN, LU, ZHAO, YU, SHI, HUAIYIN, MA, CHAO, WEI, LIXIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - physiology Blotting, Western Cell culture Cell Line, Tumor Cellular proteins Cytoskeletal Proteins - metabolism Development and progression Disease Models, Animal Female Flow Cytometry Gene expression Gene Expression Regulation, Neoplastic - physiology Genetic aspects Health aspects Heterografts Humans Inhibitor of Apoptosis Proteins - biosynthesis Kinases LIM Domain Proteins - metabolism LMP-1 Lymphoma Lymphoma, Extranodal NK-T-Cell - metabolism Lymphoma, Extranodal NK-T-Cell - pathology Lymphomas Mice Mice, Inbred BALB C Mice, Nude nasal NK/T-cell lymphoma NF-kappa B - metabolism NF-κB Nose Neoplasms - metabolism Nose Neoplasms - pathology PI3K/Akt Properties Proteins Proto-Oncogene Proteins c-akt - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - physiology Studies Survivin Transfection transplanted tumor Tumors
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