Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development
This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups receive chronic MK-801 alone or sali...
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| Veröffentlicht in: | European journal of pharmacology 1994-08, Vol.261 (1), p.1-9 |
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| container_title | European journal of pharmacology |
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| creator | Haberny, Kathleen A. Young, Gerald A. |
| description | This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups receive chronic MK-801 alone or saline. On day 8 all rats received morphine alone. Co-treatment significantly accelerated the development of tolerance to morphine-induced total power and latency to sleep onset. Co-treatment, but not morphine alone, produced tolerance to morphine-induced complexity and edge frequency, and produced tolerance equal to that from morphine alone in duration of EEG bursting. MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity. |
| doi_str_mv | 10.1016/0014-2999(94)90293-3 |
| format | Article |
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MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(94)90293-3</identifier><identifier>PMID: 8001630</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analgesics ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Dizocilpine Maleate - pharmacology ; Drug Interactions ; Drug Tolerance ; EEG (electroencephalography) ; EEG power spectra ; Electrodes, Implanted ; Electroencephalography - drug effects ; Female ; Interaction ; Medical sciences ; MK-801 ; Morphine ; Morphine - pharmacology ; Neuropharmacology ; Pharmacology. 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Morphine tolerance development</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups receive chronic MK-801 alone or saline. On day 8 all rats received morphine alone. Co-treatment significantly accelerated the development of tolerance to morphine-induced total power and latency to sleep onset. Co-treatment, but not morphine alone, produced tolerance to morphine-induced complexity and edge frequency, and produced tolerance equal to that from morphine alone in duration of EEG bursting. MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Drug Interactions</subject><subject>Drug Tolerance</subject><subject>EEG (electroencephalography)</subject><subject>EEG power spectra</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Interaction</subject><subject>Medical sciences</subject><subject>MK-801</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sleep - drug effects</subject><subject>Tolerance</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi1EVaaFNwDJC4SK1JRrOz82CyRUDWVEKzawthznWjVK4mBnBiH14XE6wyy7sRff-a6vDyGvGVwxYPUHAFYWXCl1ocr3CrgShXhGVkw2qoCG8edkdURekLOUfgFApXh1Sk5lTmoBK_KwGWeMxs5-hxSdQzsnGhy9-1ZIYNSMHR1CnO79iDSMdL2-uVwOOoU_GGmaMh_NI9bivdn5EKkfaTRz-kg3V_Tuf3cOfX5mtEg73GEfpgHH-SU5caZP-Opwn5OfX9Y_rr8Wt99vNtefbwsrBJ-LjhkQqhHCsE4ih8pxVzNmJJaN48YIA1YK5xTUsjUtVm2dfwmsqpztaleLc_JuP3eK4fcW06wHnyz2vRkxbJNmdS2hgSaD5R60MaQU0ekp-sHEv5qBXqTrxahejGpV6kfpWuTam8P8bTtgdywdLOf87SE3yZreLSJ8OmIlZ1JWPGOf9hhmFzuPUSfrMTvrfMyedRf803v8A3WynIM</recordid><startdate>19940811</startdate><enddate>19940811</enddate><creator>Haberny, Kathleen A.</creator><creator>Young, Gerald A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>19940811</creationdate><title>Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development</title><author>Haberny, Kathleen A. ; Young, Gerald A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-d1a039733a1d8e205f2f611a8e47f2aa3a0c83ff9068babe5b69250155fcd6f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Drug Interactions</topic><topic>Drug Tolerance</topic><topic>EEG (electroencephalography)</topic><topic>EEG power spectra</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Interaction</topic><topic>Medical sciences</topic><topic>MK-801</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sleep - drug effects</topic><topic>Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haberny, Kathleen A.</creatorcontrib><creatorcontrib>Young, Gerald A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haberny, Kathleen A.</au><au>Young, Gerald A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1994-08-11</date><risdate>1994</risdate><volume>261</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups receive chronic MK-801 alone or saline. On day 8 all rats received morphine alone. Co-treatment significantly accelerated the development of tolerance to morphine-induced total power and latency to sleep onset. Co-treatment, but not morphine alone, produced tolerance to morphine-induced complexity and edge frequency, and produced tolerance equal to that from morphine alone in duration of EEG bursting. MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8001630</pmid><doi>10.1016/0014-2999(94)90293-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of pharmacology, 1994-08, Vol.261 (1), p.1-9 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analgesics Animals Behavior, Animal - drug effects Biological and medical sciences Dizocilpine Maleate - pharmacology Drug Interactions Drug Tolerance EEG (electroencephalography) EEG power spectra Electrodes, Implanted Electroencephalography - drug effects Female Interaction Medical sciences MK-801 Morphine Morphine - pharmacology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Sleep - drug effects Tolerance |
| title | Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development |
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