Temporal endogenous gene expression profiles in response to polymer-mediated transfection and profile comparison to lipid-mediated transfection

Background Design of efficient nonviral gene delivery systems is limited by the rudimentary understanding of specific molecules that facilitate transfection. Methods Polyplexes using 25‐kDa polyethylenimine (PEI) and plasmid‐encoding green fluorescent protein (GFP) were delivered to HEK 293T cells....

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Veröffentlicht in:	The journal of gene medicine 2015-01, Vol.17 (1-2), p.33-53
Hauptverfasser:	Martin, Timothy M., Plautz, Sarah A., Pannier, Angela K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Gene Expression Profiling Gene Regulatory Networks Gene therapy Genes, Reporter GFP HEK 293 HEK293 Cells Humans LF2000 microarray analysis nonviral gene delivery PEI Polyethyleneimine Polymers Signal Transduction temporal gene expression profile Time Factors Transcriptome Transfection
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